Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Morc2atm1.1Pngr mutation
(0 available);
any
Morc2a mutation
(58 available)
Mphosph8tm1c(EUCOMM)Wtsi mutation
(0 available);
any
Mphosph8 mutation
(40 available)
Tg(Nes-cre)1Kln mutation
(4 available)
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mortality/aging
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• more so than in either single conditional knock-out mouse
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nervous system
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• increased brain to body ratio
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craniofacial
growth/size/body
skeleton
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Morc2atm1.1Pngr mutation
(0 available);
any
Morc2a mutation
(58 available)
Tg(Nes-cre)1Kln mutation
(4 available)
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mortality/aging
nervous system
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• dorsoventral and mediolateral expansion, predominantly of the collicular (tectal) and tegmental regions of the midbrain
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• increased neuronal activation throughout the cortex and reduced activation in the posterior brain
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behavior/neurological
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N |
• mice exhibit normal performance in a Y-maze, elevated plus maze, and Morris water maze
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• improved hippocampal-dependent fear-context memory
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• reduced motor performance and impaired motor function on a rotarod
• however, mice do not exhibit ataxia and have normal gaits
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• in PhenoMaster cages and open field tests
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craniofacial
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• varying degrees of cranial alterations from normal to moderately domed
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growth/size/body
skeleton
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• varying degrees of cranial alterations from normal to moderately domed
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Analysis Tools