Phenotypes associated with this allele

• Allele Symbol: Trex1^em3Gpt
• Allele Name: endonuclease-mediated mutation 3, GemPharmatech Co., Ltd
• Allele ID: MGI:7408568
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trex1^em3Gpt/Trex1^em3Gpt	C57BL/6JGpt-Trex1^em3Gpt	MGI:7410897

Genotype
MGI:7410897

hm1

• Allelic Composition: Trex1^em3Gpt/Trex1^em3Gpt
• Genetic Background: C57BL/6JGpt-Trex1^em3Gpt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:330879 )

immune system

enlarged spleen ( J:330879 )

increased spleen weight ( J:330879 )

increased circulating tumor necrosis factor level ( J:330879 )

increased susceptibility to autoimmune disorder ( J:330879 )

• increased immune cell infiltration in the liver, heart, and lung with increased serum levels of TNF, CXCL1. CCL5, and total IgG

growth/size/body

decreased body size ( J:330879 )

decreased body weight ( J:330879 )

enlarged spleen ( J:330879 )

increased spleen weight ( J:330879 )

homeostasis/metabolism

increased circulating tumor necrosis factor level ( J:330879 )

hematopoietic system

enlarged spleen ( J:330879 )

increased spleen weight ( J:330879 )