Phenotypes associated with this allele

• Allele Symbol: Lncenc1^em1Smoc
• Allele Name: endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• Allele ID: MGI:7386898
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lncenc1^em1Smoc/Lncenc1^em1Smoc	C57BL/6J-Lncenc1^em1Smoc	MGI:7386908

Genotype
MGI:7386908

hm1

• Allelic Composition: Lncenc1^em1Smoc/Lncenc1^em1Smoc
• Genetic Background: C57BL/6J-Lncenc1^em1Smoc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:306153 )

• when mice are fed a high-fat diet

decreased circulating cholesterol level ( J:306153 )

• when mice are fed a high-fat diet

decreased circulating HDL cholesterol level ( J:306153 )

• when mice are fed a high-fat diet

decreased circulating LDL cholesterol level ( J:306153 )

• when mice are fed a high-fat diet

decreased circulating triglyceride level ( J:306153 )

• when mice are fed a high-fat diet

increased oxygen consumption ( J:306153 )

decreased respiratory quotient ( J:306153 )

• moderate during the day and the night

impaired glucose tolerance ( J:306153 )

• when fed normal chow

improved glucose tolerance ( J:306153 )

• when mice are fed a high-fat diet

increased insulin sensitivity ( J:306153 )

• when mice are fed a high-fat diet

insulin resistance ( J:306153 )

• when fed normal chow

decreased liver cholesterol level ( J:306153 )

• when mice are fed a high-fat diet

decreased liver triglyceride level ( J:306153 )

• when mice are fed a high-fat diet

adipose tissue

decreased total body fat amount ( J:306153 )

• when mice are fed a high-fat diet

decreased brown adipose tissue mass ( J:306153 )

• when mice are fed a high-fat diet

decreased brown fat cell size ( J:306153 )

• when mice are fed a high-fat diet

• however, mice exhibit normal brown fat cell size when fed standard chow

decreased white fat cell size ( J:306153 )

• in epididymal white adipose tissue in mice fed standard chow

• in epididymal and inguinal fat pads of mice fed high-fat diet

• however, inguinal white adipose tissue and brown adipose tissue fat cell size are normal

decreased epididymal fat pad weight ( J:306153 )

• in mice fed standard chow or a high-fat diet

• however, inguinal white adipose tissue and brown adipose tissue

growth/size/body

decreased susceptibility to diet-induced obesity ( J:306153 )

• when mice are fed a high-fat diet

liver/biliary system

decreased liver cholesterol level ( J:306153 )

• when mice are fed a high-fat diet

decreased liver triglyceride level ( J:306153 )

• when mice are fed a high-fat diet

decreased liver weight ( J:306153 )

• acute in mice fed a high-fat diet

• however, mice fed standard chow exhibit normal liver size

decreased susceptibility to diet-induced hepatic steatosis ( J:306153 )

• when mice are fed a high-fat diet

renal/urinary system

renal/urinary system phenotype ( J:306153 )

N • mice exhibit normal liver size

behavior/neurological

behavior/neurological phenotype ( J:306153 )

N • mice exhibit normal total daily food consumption when fed standard chow or a high-fat diet