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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nesem1(cre)Smoc
endonuclease-mediated mutation 1, Shanghai Model Organisms Center
MGI:7341873
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fam171a2em1Smoc/Fam171a2em1Smoc
Nesem1(cre)Smoc/Nes+ 		involves: C57BL/6J MGI:8187602


Genotype
MGI:8187602
cn1
Allelic
Composition		 Fam171a2em1Smoc/Fam171a2em1Smoc
Nesem1(cre)Smoc/Nes+
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fam171a2em1Smoc mutation (0 available); any Fam171a2 mutation (31 available)
Nesem1(cre)Smoc mutation (0 available); any Nes mutation (82 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system physiology ( J:362731 )
• reduced accumulation of recombinant alpha-synuclein preformed fibrils following a 3-month incubation period compared to similarly treated wild-type controls

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:362731 )
• following 3-month incubation period with recombinant alpha-synuclein preformed fibrils loss of TH-positive neurons and fiber degeneration is reduced compared to similarly treated wild-type controls
• spread of phospho-ser129 alpha-synuclein pathology in key brain regions at 6 months after treatment is reduced compared to similarly treated wild-type controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory