Phenotypes associated with this allele

• Allele Symbol: Leap2^em1Jmz
• Allele Name: endonuclease-mediated mutation 1, Jeffrey M Zigman
• Allele ID: MGI:7336225
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Leap2^em1Jmz/Leap2^em1Jmz	C57BL/6N-Leap2^em1Jmz	MGI:7336681

Genotype
MGI:7336681

hm1

• Allelic Composition: Leap2^em1Jmz/Leap2^em1Jmz
• Genetic Background: C57BL/6N-Leap2^em1Jmz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:322589 )

N • mice fed standard chow exhibit normal blood glucose

decreased energy expenditure ( J:322589 )

♀

increased susceptibility to diet-induced obesity ( J:322589 )

♀ • female mice fed a high-fat diet exhibit increased body weight compared with wild-type mice

♀ • however, female mice exhibit normal fat mass, blood glucose, and acyl-ghrelin levels when fed a high-fat diet and male mice exhibit normal body weight increase in response to a high-fat diet

decreased oxygen consumption ( J:322589 )

♀ • in female mice fed a high-fat diet during the first 5 hr of the dark cycle

increased growth hormone level ( J:322589 )

• mice exhibit increased acyl-ghrelin-induced growth hormone secretion compared with wild-type mice

decreased basal metabolism ( J:322589 )

♀ • decreased heat production in female mice fed a high-fat diet during the first 5 hr of the dark cycle

♀ • however, mice exhibit normal CO2 production and respiratory exchange ration

abnormal response/metabolism to endogenous compounds ( J:322589 )

• mice exhibit increased acyl-ghrelin-induced food intake and growth hormone secretion compared with wild-type mice

behavior/neurological

abnormal eating behavior ( J:322589 )

♀ • slight reduction in the number of meals consumed in female mice fed a high-fat diet during the first 5 hr of the dark cycle

♀ • however, mice exhibit normal biggest meal and total food consumed

increased food intake ( J:322589 )

• mice exhibit increased acyl-ghrelin-induced food intake compared with wild-type mice

• in female mice fed a high-fat diet

• however, mice exhibit normal rebound feeding following a fast and food intake of standard chow

hypoactivity ( J:322589 )

♀ • in female mice fed a high-fat diet during the first 5 hr of the dark cycle

growth/size/body

growth/size/body region phenotype ( J:322589 )

N • mice fed standard chow exhibit normal body weight, length, and composition

decreased lean body mass ( J:322589 )

♀ • in female and male mice fed a high-fat diet

increased susceptibility to diet-induced obesity ( J:322589 )

♀ • female mice fed a high-fat diet exhibit increased body weight compared with wild-type mice

♀ • however, female mice exhibit normal fat mass, blood glucose, and acyl-ghrelin levels when fed a high-fat diet and male mice exhibit normal body weight increase in response to a high-fat diet

liver/biliary system

macrovesicular hepatic steatosis ( J:322589 )

♀ • more pronounced in female mice fed a high-fat diet