All Phenotypes Prmt9<em1Cya> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Prmt9^em1Cya
endonuclease-mediated mutation 1, Cyagen Biosciences
MGI:7336180

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Prmt9^em1Cya/Prmt9^em1Cya Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129P2/OlaHsd * C57BL/6N	MGI:7336222

Allelic Composition	Prmt9^em1Cya/Prmt9^em1Cya Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2^tm1(cre)Ifo mutation (16 available); any Lyz2 mutation (40 available)
Prmt9^em1Cya mutation (0 available); any Prmt9 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased circulating interferon-beta level ( J:328263 )

• in the serum of mice infected with VSV

increased interferon-beta secretion ( J:328263 )

• from macrophages infected with SeV or stimulated with 5'pppRNA

decreased susceptibility to viral infection ( J:328263 )

• mice infected with VSV exhibit reduced IFBN-beta serum levels, viral titers in the lung, liver, and spleen, inflammation, edema, and pulmonary fibrosis compared with wild-type mice

• however, response to HSV-1 infection is normal

homeostasis/metabolism

increased circulating interferon-beta level ( J:328263 )

• in the serum of mice infected with VSV

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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