Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vmn2r53em1Ktou mutation
(0 available);
any
Vmn2r53 mutation
(53 available)
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behavior/neurological
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• with the second intruder in a resident-intruder assay, male mice fail to exhibit an increase in aggression toward castrated mice swabbed in intact male urine or a Vmn2r53-activating urine fraction unlike wild-type mice
• however, mice exhibit normal aggression toward the first intruder
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• in a resident-intruder assay, male mice exhibit lower numbers of attacks and total duration of attacks compared with wild-type mice
• male mice attack less urine-swabbed castrated male intruders compared with wild-type mice
• however, mice exhibit normal percentage of attacking male mice and sex discrimination
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrtm1.1(cre)Shah mutation
(1 available);
any
Pgr mutation
(73 available)
Vmn2r53em1Ktou mutation
(0 available);
any
Vmn2r53 mutation
(53 available)
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behavior/neurological
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• mice injected with an adenovirus expressing a cre-dependent GCaMP6s exhibit no response to a first or second intruder swabbed with the Vmn2r53-activating urine fraction unlike wild-type mice
• however, mice exhibit a normal response to female and castrated male urine or mice, and injection of clozapine N-oxide (selective agonist of hM4D(Gi)) restores aggressiveness
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|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrtm1.1(cre)Shah mutation
(1 available);
any
Pgr mutation
(73 available)
Vmn2r53em1Ktou mutation
(0 available);
any
Vmn2r53 mutation
(53 available)
|
|
|
behavior/neurological
|
|
• mice injected with an adenovirus expressing a cre-dependent GCaMP6s exhibit no response to a second intruder swabbed with the Vmn2r53-activating urine fraction unlike wild-type mice
• however, mice exhibit a normal response to the first intruder, and injection of clozapine N-oxide (selective agonist of hM4D(Gi)) restores aggressiveness
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Analysis Tools