Phenotypes associated with this allele

• Allele Symbol: Trgv6^em1Dmuc
• Allele Name: endonuclease-mediated mutation 1, Daniel Mucida
• Allele ID: MGI:7328935
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trgv6^em1Dmuc/Trgv6^em1Dmuc	C57BL/6-Trgv6^em1Dmuc	MGI:8449420

Genotype
MGI:8449420

hm1

• Allelic Composition: Trgv6^em1Dmuc/Trgv6^em1Dmuc
• Genetic Background: C57BL/6-Trgv6^em1Dmuc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell subpopulation ratio ( J:327132 )

• mice exhibit a decreased gamma-delta/alpha-beta T cell ratio in fat tissue at steady state

increased gamma-delta T cell number ( J:327132 )

• mice subjected to AOM-DSS show a sharp increase in tumor-infiltrating Vgamma4+ gamma-delta T cells producing IL-17

• however, no differences in tumor-infiltrating CD4+ T cells is seen in AOM-DSS treated mice

immune system

abnormal T cell subpopulation ratio ( J:327132 )

• mice exhibit a decreased gamma-delta/alpha-beta T cell ratio in fat tissue at steady state

increased gamma-delta T cell number ( J:327132 )

• mice subjected to AOM-DSS show a sharp increase in tumor-infiltrating Vgamma4+ gamma-delta T cells producing IL-17

• however, no differences in tumor-infiltrating CD4+ T cells is seen in AOM-DSS treated mice

neoplasm

neoplasm ( J:327132 )

N • mice subjected to azoxymethane-dextran sodium sulfate (AOM-DSS) show similar colorectal cancer development, progression and parameters of tumor-infiltrating gamma-delta T cells to those seen in AOM-DSS treated controls