Phenotypes associated with this allele

• Allele Symbol: Kif2c^em1Nju
• Allele Name: endonuclease-mediated mutation 1, Model Animal Research Center of Nanjing University
• Allele ID: MGI:7328589
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kif2c^em1Nju/Kif2c^em1Nju Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL	MGI:7328688

Genotype
MGI:7328688

cn1

• Allelic Composition: Kif2c^em1Nju/Kif2c^em1Nju; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:322820 )

N • mice exhibit normal prepulse inhibition

abnormal dendritic mushroom spine morphology ( J:322820 )

• reduced mushroom spine density in basal and apical dendrites of hippocampal neurons

decreased dendritic spine density ( J:322820 )

• reduced mushroom spine density in basal and apical dendrites of hippocampal neurons

increased dendritic spine density ( J:322820 )

• increased density of filopodia-type spines

abnormal synapse morphology ( J:322820 )

• reduced length and thickness of postsynaptic density fraction in the hippocampus

abnormal excitatory postsynaptic currents ( J:322820 )

• increased AMPAR-mediated EPSCs with increased surface AMPAR receptors

increased excitatory postsynaptic current amplitude ( J:322820 )

• of mEPSCs

abnormal miniature excitatory postsynaptic currents ( J:322820 )

• increased amplitude

• however, mice exhibit normal frequency of mEPSCs and PPRs

reduced long-term depression ( J:322820 )

• following single high-frequency stimulation (1x HFS) or 4-train LTP (4x HFS)

behavior/neurological

impaired conditioned place preference behavior ( J:322820 )

• in response to context or tone conditioned stimulus, mice exhibit less freezing time compared with wild-type mice

impaired cued conditioning behavior ( J:322820 )

• in response to context or tone conditioned stimulus, mice exhibit less freezing time compared with wild-type mice

abnormal spatial working memory ( J:322820 )

• impaired spontaneous alternation in a Y maze

decreased freezing behavior ( J:322820 )

• in response to context or tone conditioned stimulus, mice exhibit less freezing time compared with wild-type mice

abnormal response to social novelty ( J:322820 )

• mice exhibit reduced investigation of a novel stranger compared with the familiar mouse

• however, mice exhibit normal social investigation and over-expression restores normal interaction in the novel stranger test