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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cep250em1Glvr
endonuclease-mediated mutation 1, Gabriel Livera
MGI:7327530
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cep250em1Glvr/Cep250em1Glvr C57BL/6-Cep250em1Glvr MGI:7327533


Genotype
MGI:7327533
hm1
Allelic
Composition		 Cep250em1Glvr/Cep250em1Glvr
Genetic
Background		 C57BL/6-Cep250em1Glvr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cep250em1Glvr mutation (0 available); any Cep250 mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:324876 )
N
• female mice exhibit normal meiosis
azoospermia ( J:324876 )
• complete absence of spermatids and spermatozoa in the seminiferous tubules
arrest of male meiosis ( J:324876 )
• meiosis arrest in prophase I with reduced leptotene and zygotene cells at 10 dpp
• however, germ cells exhibit normal mitosis to meiosis switch

cellular
azoospermia ( J:324876 )
• complete absence of spermatids and spermatozoa in the seminiferous tubules
arrest of male meiosis ( J:324876 )
• meiosis arrest in prophase I with reduced leptotene and zygotene cells at 10 dpp
• however, germ cells exhibit normal mitosis to meiosis switch

endocrine/exocrine glands




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory