Phenotypes associated with this allele

• Allele Symbol: Orc4^{tm1c(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:7314200
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Orc4^tm1c(EUCOMM)Wtsi/Orc4^tm1c(EUCOMM)Wtsi Tmem163^Tg(ACTB-cre)2Mrt/Tmem163^+	involves: C57BL/6N * FVB/N	MGI:7314207

Genotype
MGI:7314207

cn1

• Allelic Composition: Orc4^{tm1c(EUCOMM)Wtsi}/Orc4^{tm1c(EUCOMM)Wtsi}; Tmem163^{Tg(ACTB-cre)2Mrt}/Tmem163⁺
• Genetic Background: involves: C57BL/6N * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal oocyte morphology ( J:326522 )

• MII oocytes are poorly developed

abnormal polar body morphology ( J:326522 )

• reduced polar body extrusion

abnormal female meiosis ( J:326522 )

• half of cultured oocytes arrest at the germinal vesicle, meiosis I, or anaphase I stages

• MII oocytes progress to the two-cell stage without DNA synthesis

female infertility ( J:326522 )

• infertility cannot be rescued by intracytoplasmic sperm injection

cellular

abnormal oocyte morphology ( J:326522 )

• MII oocytes are poorly developed

abnormal polar body morphology ( J:326522 )

• reduced polar body extrusion

abnormal female meiosis ( J:326522 )

• half of cultured oocytes arrest at the germinal vesicle, meiosis I, or anaphase I stages

• MII oocytes progress to the two-cell stage without DNA synthesis