Phenotypes associated with this allele

• Allele Symbol: Sh3rf1^em1Bcgen
• Allele Name: endonuclease-mediated mutation 1, Biocytogen LLC
• Allele ID: MGI:7312050
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sh3rf1^em1Bcgen/Sh3rf1^em1Bcgen Tg(Nes-cre)1Kln/0 Tg(Thy1-EGFP)MJrs/0	involves: C57BL/6 * CBA * SJL	MGI:7312058
cn2	Sh3rf1^em1Bcgen/Sh3rf1^em1Bcgen Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL	MGI:7312057

Genotype
MGI:7312058

cn1

• Allelic Composition: Sh3rf1^em1Bcgen/Sh3rf1^em1Bcgen; Tg(Nes-cre)1Kln/0; Tg(Thy1-EGFP)MJrs/0
• Genetic Background: involves: C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased dendritic spine density ( J:326378 )

• reduction in the number and volume of mushroom, thin, and filopodium spines

• however, stubby spine numbers are normal

decreased dendritic spine length ( J:326378 )

• with reduced complexity

Genotype
MGI:7312057

cn2

• Allelic Composition: Sh3rf1^em1Bcgen/Sh3rf1^em1Bcgen; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * SJL

nervous system

decreased excitatory postsynaptic current amplitude ( J:326378 )

• NMDAR-mediated

• however, AMPAR-evoked currents are normal

reduced long-term potentiation ( J:326378 )

behavior/neurological

impaired contextual conditioning behavior ( J:326378 )

impaired spatial learning ( J:326378 )

• in a Morris water maze task, mice take a longer time to reach a hidden platform compared with wild-type mice

abnormal spatial reference memory ( J:326378 )

• impaired in an eight-armed maze test

hypoactivity ( J:326378 )

• slight in an open field

increased stereotypic behavior ( J:326378 )

• increased time digging under a novel condition

• however, no increase in grooming is observed

abnormal nest building behavior ( J:326378 )

• impaired

decreased social investigation ( J:326378 )

• reduced interactions in free same-sex social interactions

decreased vocalization ( J:326378 )

• less frequent and shorter vocalizations in female and male mice

growth/size/body

decreased body weight ( J:326378 )

• slightly

taste/olfaction

taste/olfaction phenotype ( J:326378 )

N • mice exhibit normal olfaction