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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nucb2tm1.1Vdix
targeted mutation 1.1, Vishwa Deep Dixit
MGI:7310446
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Nucb2tm1.1Vdix/Nucb2tm1.1Vdix
Tg(Adipoq-cre/Esr1*)1Evdr/0 		involves: 129 * C57BL/6 MGI:7310457
cn2
 		Nucb2tm1.1Vdix/Nucb2tm1.1Vdix
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:7310456


Genotype
MGI:7310457
cn1
Allelic
Composition		 Nucb2tm1.1Vdix/Nucb2tm1.1Vdix
Tg(Adipoq-cre/Esr1*)1Evdr/0
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nucb2tm1.1Vdix mutation (0 available); any Nucb2 mutation (30 available)
Tg(Adipoq-cre/Esr1*)1Evdr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
growth/size/body region phenotype ( J:270674 )
N
• mice fed a high-fat diet exhibit normal diet-induced obesity

homeostasis/metabolism
abnormal glucose homeostasis ( J:270674 )
• mice fed a high-fat diet exhibit normal glucose intolerance




Genotype
MGI:7310456
cn2
Allelic
Composition		 Nucb2tm1.1Vdix/Nucb2tm1.1Vdix
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
Nucb2tm1.1Vdix mutation (0 available); any Nucb2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
impaired glucose tolerance ( J:270674 )
• mice fed a high-fat diet exhibit worsened glucose intolerance and insulin sensitivity
insulin resistance ( J:270674 )
• mice fed a high-fat diet exhibit worsened glucose intolerance and insulin sensitivity

growth/size/body
growth/size/body region phenotype ( J:270674 )
N
• mice fed a high-fat diet exhibit normal diet-induced obesity




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory