Analysis Tools
growth/size/body
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• at 4 months of age, mice fed a normal chow diet (NCD) show a slight increase in body weight relative to NCD-fed wild-type controls; increase is only significant in females
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• 8-week-old male mice fed a high-fat diet (HFD) for 12 weeks gain more weight and show higher percentages of fat mass than HFD-fed wild-type controls
• however, no differences in food intake are observed on a NCD or a HFD
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• HFD-fed mice exhibit a greater increase in liver weight and liver weight/body weight ratio than HFD-fed wild-type controls
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homeostasis/metabolism
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• after oral oil gavage, HFD-fed mice exhibit higher plasma TG levels than HFD-fed wild-type controls but no differences in hepatic very-low-density lipoprotein-TG secretion, indicating increased intestinal triglyceride absorption
• quantitative TG measurement and Oil red O staining of the proximal jejunum confirmed enhanced postprandial lipid accumulation in the small intestine villi
• however, small intestine length and duodenum villus length remain normal
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• 8-week-old male mice fed a high-fat diet (HFD) for 12 weeks gain more weight and show higher percentages of fat mass than HFD-fed wild-type controls
• however, no differences in food intake are observed on a NCD or a HFD
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• HFD-fed mice exhibit more severe fasting hyperglycemia than HFD-fed wild-type controls
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• HFD-fed mice exhibit more severe fasting hyperinsulinemia than HFD-fed wild-type controls
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• HFD-fed mice display higher plasma cholesterol levels than HFD-fed wild-type controls
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• HFD-fed mice display slightly higher plasma triglycerides (TG) levels than HFD-fed wild-type controls
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• HFD-fed mice exhibit higher plasma alanine aminotransferase (ALT) levels than HFD-fed wild-type controls, indicating more severe liver injury
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• HFD-fed mice exhibit worsened glucose tolerance relative to HFD-fed wild-type controls
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• when fed a HFD diet for 11 weeks, male mice develop more severe insulin resistance than HFD-fed wild-type controls
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• HFD-fed mice exhibit higher liver cholesterol levels than HFD-fed wild-type controls
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• HFD-fed mice exhibit higher liver TG levels than HFD-fed wild-type controls
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liver/biliary system
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• HFD-fed mice exhibit a greater increase in liver weight and liver weight/body weight ratio than HFD-fed wild-type controls
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• HFD-fed mice exhibit higher liver cholesterol levels than HFD-fed wild-type controls
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• HFD-fed mice exhibit higher liver TG levels than HFD-fed wild-type controls
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• male mice fed a high-fat diet (HFD) for 12 weeks exhibit an enlarged liver, increased liver weight and liver weight/body weight ratio, increased liver cholesterol and TG levels, and more severe hepatic lipid accumulation and liver injury than HFD-fed wild-type controls
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digestive/alimentary system
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• after oral oil gavage, HFD-fed mice exhibit higher plasma TG levels than HFD-fed wild-type controls but no differences in hepatic very-low-density lipoprotein-TG secretion, indicating increased intestinal triglyceride absorption
• quantitative TG measurement and Oil red O staining of the proximal jejunum confirmed enhanced postprandial lipid accumulation in the small intestine villi
• however, small intestine length and duodenum villus length remain normal
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