Phenotypes associated with this allele

• Allele Symbol: Wiz^em1Ccpcz
• Allele Name: endonuclease-mediated mutation 1, Institute of Molecular Genetics
• Allele ID: MGI:7310064
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wiz^em1Ccpcz/Wiz^em1Ccpcz	involves: C57BL/6N	MGI:7310066

Genotype
MGI:7310066

hm1

• Allelic Composition: Wiz^em1Ccpcz/Wiz^em1Ccpcz
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:308697 )

• subviable at E185, with some dead embryos seen as early as E12.5

perinatal lethality, complete penetrance ( J:308697 )

growth/size/body

cleft palate ( J:308697 )

• at E12.5, 7 of 12 had full cleft palate and 5 of 12 had incomplete shelf fusion

delayed palatal shelf elevation ( J:308697 )

• delay in horizontalization at E14.5 and no signs of horizontalization are seen even at E15.5

short snout ( J:308697 )

• at E18.5

decreased fetal size ( J:308697 )

• about a 25% reduction in crown to rump length at E18.5

vision/eye

abnormal eyelid development ( J:308697 )

• underdeveloped at E18.5

• cleft eyelids

digestive/alimentary system

cleft palate ( J:308697 )

• at E12.5, 7 of 12 had full cleft palate and 5 of 12 had incomplete shelf fusion

delayed palatal shelf elevation ( J:308697 )

• delay in horizontalization at E14.5 and no signs of horizontalization are seen even at E15.5

craniofacial

cleft palate ( J:308697 )

• at E12.5, 7 of 12 had full cleft palate and 5 of 12 had incomplete shelf fusion

delayed palatal shelf elevation ( J:308697 )

• delay in horizontalization at E14.5 and no signs of horizontalization are seen even at E15.5

short snout ( J:308697 )

• at E18.5