All Phenotypes Fxyd5<em1Namje> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fxyd5^em1Namje
endonuclease-mediated mutation 1, Jeong-Seok Nam
MGI:7310029

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fxyd5^em1Namje/Fxyd5^em1Namje	C57BL/6J-Fxyd5^em1Namje	MGI:7310031
cx2	Apc^Min/Apc⁺ Fxyd5^em1Namje/Fxyd5^em1Namje	C57BL/6J-Fxyd5^em1Namje Apc^min	MGI:7310033

Allelic Composition	Fxyd5^em1Namje/Fxyd5^em1Namje
Genetic Background	C57BL/6J-Fxyd5^em1Namje

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fxyd5^em1Namje mutation (0 available); any Fxyd5 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:325989 )

N	• injected tumors (MC38) exhibit normal tumor seeding and growth

decreased incidence of tumors by chemical induction ( J:325989 )

• following treatment with azoxymethane/dextran sodium sulfate, mice exhibit fewer colon tumors than in similarly treated wild-type mice

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:325989 )

• following treatment with azoxymethane/dextran sodium sulfate, mice exhibit fewer colon tumors than in similarly treated wild-type mice

Allelic Composition	Apc^Min/Apc⁺ Fxyd5^em1Namje/Fxyd5^em1Namje
Genetic Background	C57BL/6J-Fxyd5^em1Namje Apc^min

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (154 available)
Fxyd5^em1Namje mutation (0 available); any Fxyd5 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased gastrointestinal tumor incidence ( J:325989 )

• mice develop intestinal tumors unlike wild-type mice but at a slower rate and with reduced tumor load and invasiveness compared with mice homozygous for the wild-type Fxyd5 allele

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:325989 )

• mice develop intestinal tumors unlike wild-type mice but at a slower rate and with reduced tumor load and invasiveness compared with mice homozygous for the wild-type Fxyd5 allele

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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