Analysis Tools
reproductive system
azoospermia
(
J:335565
)
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• no spermatozoa are seen in the epididymis
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• males show rescue of spermatogenesis, with diplotene and metaphase I cells in testes and the presence of post-meiotic cells which can escape the checkpoint elimination and develop into round or elongating spermatids, but fewer post-meiotic cells are seen than in wild-type males
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• partial rescue of the oogenesis defects seen in single homozygous Spidr mutant females such that ovaries have follicles at various stages of oocyte development unlike single homozygous Spidr mutant females and oocyte loss is partially rescued such that females are able to produce more offspring than single homozygous Spidr mutants but still less than in wild-type females
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• oocyte loss is partially rescued in adults, and females are able to produce more offspring than single homozygous Spidr mutant females within 6 months but still less than in wild-type females
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• females exhibit partial rescue of the subfertility seen in single homozygous Spidr mutants such that females are able to produce more offspring than single homozygous Spidr mutants but still lower fertility than in wild-type females
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• males, but not females, are infertile
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cellular
azoospermia
(
J:335565
)
|
|
• no spermatozoa are seen in the epididymis
|
|
|
• males show rescue of spermatogenesis, with diplotene and metaphase I cells in testes and the presence of post-meiotic cells which can escape the checkpoint elimination and develop into round or elongating spermatids, but fewer post-meiotic cells are seen than in wild-type males
|
|
|
• partial rescue of the oogenesis defects seen in single homozygous Spidr mutant females such that ovaries have follicles at various stages of oocyte development unlike single homozygous Spidr mutant females and oocyte loss is partially rescued such that females are able to produce more offspring than single homozygous Spidr mutants but still less than in wild-type females
|
|
|
• oocyte loss is partially rescued in adults, and females are able to produce more offspring than single homozygous Spidr mutant females within 6 months but still less than in wild-type females
|
