All Phenotypes Bud31<em1Gpt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bud31^em1Gpt
endonuclease-mediated mutation 1, GemPharmatech
MGI:7296069

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bud31^em1Gpt/Bud31^em1Gpt Stra8^{em1(GFP/cre)Smoc}/Stra8⁺	involves: C57BL/6JGpt	MGI:8288388
cn2	Bud31^em1Gpt/Bud31^em1Gpt Tg(Ddx4-cre)1Dcas/0	involves: C57BL/6JGpt * FVB	MGI:8288381

Allelic Composition	Bud31^em1Gpt/Bud31^em1Gpt Stra8^{em1(GFP/cre)Smoc}/Stra8⁺
Genetic Background	involves: C57BL/6JGpt

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bud31^em1Gpt mutation (0 available); any Bud31 mutation (18 available)
Stra8^{em1(GFP/cre)Smoc} mutation (0 available); any Stra8 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal male meiosis ( J:333861 )

• male germ cells fail to enter meiosis

• meiotic cells are reduced at P10 and P12 and no spermatocytes later than those with preleptotene stage chromosomes are seen in testes at P12

• no meiotic cells are seen in testes at P17, a time when pachytene chromosomes are seen in control testes

small testis ( J:333861 )

arrest of spermatogenesis ( J:333861 )

• P10 testes show reduced levels of genes involved in spermatogonia differentiation and male germ cells fail to enter meiosis

male infertility ( J:333861 )

endocrine/exocrine glands

small testis ( J:333861 )

cellular

abnormal male meiosis ( J:333861 )

• male germ cells fail to enter meiosis

• meiotic cells are reduced at P10 and P12 and no spermatocytes later than those with preleptotene stage chromosomes are seen in testes at P12

• no meiotic cells are seen in testes at P17, a time when pachytene chromosomes are seen in control testes

Allelic Composition	Bud31^em1Gpt/Bud31^em1Gpt Tg(Ddx4-cre)1Dcas/0
Genetic Background	involves: C57BL/6JGpt * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bud31^em1Gpt mutation (0 available); any Bud31 mutation (18 available)
Tg(Ddx4-cre)1Dcas mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased male germ cell number ( J:333861 )

• decrease in the number of germ cells in the testes

decreased spermatogonia number ( J:333861 )

• significant loss of spermatogonial stem cells

small testis ( J:333861 )

male infertility ( J:333861 )

• no pups are obtained when adult males are mated with wild-type females indicating male infertility

endocrine/exocrine glands

small testis ( J:333861 )

cellular

decreased male germ cell number ( J:333861 )

• decrease in the number of germ cells in the testes

decreased spermatogonia number ( J:333861 )

• significant loss of spermatogonial stem cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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