Phenotypes associated with this allele

• Allele Symbol: Vcp^em1Kene
• Allele Name: endonuclease-mediated mutation 1, Ken Ebihara
• Allele ID: MGI:7284311
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Vcp^em1Kene/Vcp^+	C57BL/6J-Vcp^em1Kene	MGI:7284337

Genotype
MGI:7284337

ht1

• Allelic Composition: Vcp^em1Kene/Vcp⁺
• Genetic Background: C57BL/6J-Vcp^em1Kene

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:325062 )

N • normal plasma glucose and insulin levels when fed high fat diet (HFD)

N • normal intraperitoneal glucose tolerance test (IPGTT) when fed high fat diet (HFD)

N • normal plasma nonesterified fatty acid (NEFA) and total cholesterol levels when fed high fat diet (HFD)

N • normal liver ATP levels at age 20 weeks when fed high fat diet (HFD)

decreased susceptibility to diet-induced obesity ( J:325062 )

• reduced liver enlargement, weight increase and triglyceride levels when fed high fat diet (HFD)

• reduced size and number of lipid droplets in liver when fed high fat diet (HFD)

increased susceptibility to diet-induced obesity ( J:325062 )

• greater increase in epididymal white adipose tissue (eWAT) mass when fed high fat diet (HFD)

• larger adipocytes in epididymal white adipose tissue (eWAT) when fed high fat diet (HFD)

increased circulating triglyceride level ( J:325062 )

• when fed high fat diet (HFD)

increased insulin sensitivity ( J:325062 )

• as measured by intraperitoneal insulin tolerance test (IPITT) when fed high fat diet (HFD)

growth/size/body

growth/size/body region phenotype ( J:325062 )

N • normal liver and epididymal white adipose tissue (eWAT) weights, liver histology and liver TG content when fed standard diet

decreased body weight ( J:325062 )

• from birth when fed standard diet

• normal when fed high fat diet (HFD) from age 8 weeks

decreased susceptibility to diet-induced obesity ( J:325062 )

• reduced liver enlargement, weight increase and triglyceride levels when fed high fat diet (HFD)

• reduced size and number of lipid droplets in liver when fed high fat diet (HFD)

increased susceptibility to diet-induced obesity ( J:325062 )

• greater increase in epididymal white adipose tissue (eWAT) mass when fed high fat diet (HFD)

• larger adipocytes in epididymal white adipose tissue (eWAT) when fed high fat diet (HFD)

cellular

cellular phenotype ( J:325062 )

N • no signs of ER stress in liver at age 20 weeks when fed high fat diet (HFD)