Phenotypes associated with this allele

• Allele Symbol: Brme1^em1Amp
• Allele Name: endonuclease-mediated mutation 1, Alberto M Pendas
• Allele ID: MGI:7281853
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Brme1^em1Amp/Brme1^em1Amp	involves: C57BL/6J * CBA/J	MGI:7282046

Genotype
MGI:7282046

hm1

• Allelic Composition: Brme1^em1Amp/Brme1^em1Amp
• Genetic Background: involves: C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

azoospermia ( J:303558 )

♂ • testes lack spermatozoa

abnormal chromosomal synapsis ( J:303558 )

• spermatocytes are partially synapsed and show a partner-switch phenotype in which synapsis is not restricted to homologous pairs indicating that arrest corresponds to a zygotene-like stage, though a small fraction of cells escape this blockage and reach pachytene

• oocytes show the presence of a subset of fully synapsed pachynemas but also an increased number of cells with different degree of asynapsis

abnormal male meiosis ( J:303558 )

♂ • meiotic arrest at epithelial stage IV with apoptotic spermatocytes

abnormal ovarian follicle number ( J:303558 )

♀ • females are fertile but show a strong reduction of the follicle pool

small testis ( J:303558 )

♂ • 76% reduction in testis size

arrest of spermatogenesis ( J:303558 )

♂ • meiotic arrest at epithelial stage IV with apoptotic spermatocytes

male infertility ( J:303558 )

♂

endocrine/exocrine glands

abnormal ovarian follicle number ( J:303558 )

♀ • females are fertile but show a strong reduction of the follicle pool

small testis ( J:303558 )

♂ • 76% reduction in testis size

cellular

azoospermia ( J:303558 )

♂ • testes lack spermatozoa

abnormal chromosomal synapsis ( J:303558 )

• spermatocytes are partially synapsed and show a partner-switch phenotype in which synapsis is not restricted to homologous pairs indicating that arrest corresponds to a zygotene-like stage, though a small fraction of cells escape this blockage and reach pachytene

• oocytes show the presence of a subset of fully synapsed pachynemas but also an increased number of cells with different degree of asynapsis

abnormal male meiosis ( J:303558 )

♂ • meiotic arrest at epithelial stage IV with apoptotic spermatocytes