All Phenotypes Phf6<em1Wencc> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Phf6^em1Wencc/Phf6^em1Wencc Tg(Vav1-cre)#Cgp/0	Not Specified	MGI:7280785
cn2	Phf6^em1Wencc/Y Tg(Vav1-cre)#Cgp/0	Not Specified	MGI:7280786

Allelic Composition	Phf6^em1Wencc/Phf6^em1Wencc Tg(Vav1-cre)#Cgp/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phf6^em1Wencc mutation (0 available); any Phf6 mutation (10 available)
Tg(Vav1-cre)#Cgp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:278804 )

• normal spleen and thymus weight and histology at age 8-12 weeks

• normal percentage of B cells in spleen at age 8-12 weeks

• normal total, naive regulatory and effector T cell function in cytokine stimulation assays at age 8-12 weeks

• normal number of B cells in bone marrow other than pro-B cells at age 8-12 weeks

• normal number of long-term hematopoietic stem cells (LT-HSCs) in bone marrow at age 8-12 weeks

abnormal thymus cell ratio ( J:278804 )

• reduced CD4- CD8- double-negative T cell numbers at age 8-12 weeks

enlarged spleen ( J:278804 )

• at age 18 months

• normal spleen weight and histology at age 8-12 weeks

increased pro-B cell number ( J:278804 )

• in bone marrow at age 8-12 weeks

abnormal effector T cell number ( J:278804 )

• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen at age 8-12 weeks

decreased lymphocyte cell number ( J:278804 )

• in blood at age 18 months

decreased double-negative T cell number ( J:278804 )

• reduced in thymus at age 8-12 weeks

decreased CD4-positive, alpha-beta T cell number ( J:278804 )

• at age 8-12 weeks

• normal percentage in spleen at age 8-12 weeks

decreased CD8-positive, alpha-beta T cell number ( J:278804 )

• at age 8-12 weeks

• reduced percentage in spleen at age 8-12 weeks

increased leukocyte cell number ( J:278804 )

• at age 8 weeks

increased B cell number ( J:278804 )

• more B220+ cells at ages 8-12 weeks and 18 months

• normal percentage of B cells in spleen at age 8-12 weeks

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:278804 )

• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells in spleen at age 8-12 weeks

abnormal splenic cell ratio ( J:278804 )

• reduced percentage of T cells at age 8-12 weeks

• reduced percentage of CD8+ T cells at ages 8-12 weeks and 18 months

• increased percentage of CD4+ T cells at age 18 months

• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells at ages 8-12 weeks and 18 months

• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen ages 8-12 weeks and 18 months

• normal percentage of CD4+ T cells at age 8-12 weeks

• normal percentage of B cells at age 8-12 weeks

hematopoietic system

increased hematopoietic stem cell proliferation ( J:278804 )

• reduced number of type 2 and 3 multi-potent progenitor cells (MMP2s, MPP3s), LSK and long-term hematopoietic stem cells (LT-HSCs) in G0 cell cycle phase in bone marrow at age 8-12 weeks

abnormal thymus cell ratio ( J:278804 )

• reduced CD4- CD8- double-negative T cell numbers at age 8-12 weeks

enlarged spleen ( J:278804 )

• at age 18 months

• normal spleen weight and histology at age 8-12 weeks

increased pro-B cell number ( J:278804 )

• in bone marrow at age 8-12 weeks

extramedullary hematopoiesis ( J:278804 )

• in spleen red pulp at age 18 months

decreased bone marrow cell number ( J:278804 )

• reduced number of LK and Lin- cells at age 8-12 weeks

increased bone marrow cell number ( J:278804 )

• increased number of type 2 multi-potent progenitor cells (MPP2s) at age 8-12 weeks

decreased granulocyte monocyte progenitor cell number ( J:278804 )

• in bone marrow at age 8-12 weeks

abnormal megakaryocyte morphology ( J:278804 )

• hyper- and dysplastic, smaller and with hypolobulated nuclei in bone marrow at age 18 months

increased megakaryocyte cell number ( J:278804 )

• hyperplastic in bone marrow at age 18 months

thrombocytopenia ( J:278804 )

• in blood at age 18 months

abnormal effector T cell number ( J:278804 )

• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen at age 8-12 weeks

decreased lymphocyte cell number ( J:278804 )

• in blood at age 18 months

decreased double-negative T cell number ( J:278804 )

• reduced in thymus at age 8-12 weeks

decreased CD4-positive, alpha-beta T cell number ( J:278804 )

• normal percentage in spleen at age 8-12 weeks

• at age 8-12 weeks

decreased CD8-positive, alpha-beta T cell number ( J:278804 )

• at age 8-12 weeks

• reduced percentage in spleen at age 8-12 weeks

increased leukocyte cell number ( J:278804 )

• at age 8 weeks

increased B cell number ( J:278804 )

• more B220+ cells at ages 8-12 weeks and 18 months

• normal percentage of B cells in spleen at age 8-12 weeks

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:278804 )

• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells in spleen at age 8-12 weeks

decreased hematopoietic stem cell number ( J:278804 )

• reduced number of long-term hematopoietic stem cells (LT-HSCs) in bone marrow at age 18 months

increased hematopoietic stem cell number ( J:278804 )

• in bone marrow at age 8-12 weeks

abnormal splenic cell ratio ( J:278804 )

• reduced percentage of T cells at age 8-12 weeks

• reduced percentage of CD8+ T cells at ages 8-12 weeks and 18 months

• increased percentage of CD4+ T cells at age 18 months

• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells at ages 8-12 weeks and 18 months

• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen ages 8-12 weeks and 18 months

• normal percentage of CD4+ T cells at age 8-12 weeks

• normal percentage of B cells at age 8-12 weeks

endocrine/exocrine glands

abnormal thymus cell ratio ( J:278804 )

• reduced CD4- CD8- double-negative T cell numbers at age 8-12 weeks

growth/size/body

enlarged spleen ( J:278804 )

• at age 18 months

• normal spleen weight and histology at age 8-12 weeks

cellular

increased hematopoietic stem cell proliferation ( J:278804 )

• reduced number of type 2 and 3 multi-potent progenitor cells (MMP2s, MPP3s), LSK and long-term hematopoietic stem cells (LT-HSCs) in G0 cell cycle phase in bone marrow at age 8-12 weeks

skeleton

skeleton phenotype ( J:278804 )

N	• normal bone marrow cellularity and architecture at ages 8-12 weeks and 18 months

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased hematopoietic stem cell proliferation ( J:278804 )

• reduced number of type 2 and 3 multi-potent progenitor cells (MMP2s, MPP3s), LSK and long-term hematopoietic stem cells (LT-HSCs) in G0 cell cycle phase in bone marrow at age 8-12 weeks

endocrine/exocrine glands

abnormal thymus cell ratio ( J:278804 )

• reduced CD4- CD8- double-negative T cell numbers at age 8-12 weeks

growth/size/body

enlarged spleen ( J:278804 )

• at age 18 months

• normal spleen weight and histology at age 8-12 weeks

hematopoietic system

hematopoietic system phenotype ( J:278804 )

N	• normal white blood cell count (WBC) at age 8 weeks

increased hematopoietic stem cell proliferation ( J:278804 )

• reduced number of type 2 and 3 multi-potent progenitor cells (MMP2s, MPP3s), LSK and long-term hematopoietic stem cells (LT-HSCs) in G0 cell cycle phase in bone marrow at age 8-12 weeks

abnormal thymus cell ratio ( J:278804 )

• reduced CD4- CD8- double-negative T cell numbers at age 8-12 weeks

enlarged spleen ( J:278804 )

• at age 18 months

• normal spleen weight and histology at age 8-12 weeks

increased pro-B cell number ( J:278804 )

• in bone marrow at age 8-12 weeks

extramedullary hematopoiesis ( J:278804 )

• in spleen red pulp at age 18 months

decreased bone marrow cell number ( J:278804 )

• reduced number of LK and Lin- cells at age 8-12 weeks

increased bone marrow cell number ( J:278804 )

• increased number of type 2 multi-potent progenitor cells (MPP2s) at age 8-12 weeks

decreased granulocyte monocyte progenitor cell number ( J:278804 )

• in bone marrow at age 8-12 weeks

abnormal megakaryocyte morphology ( J:278804 )

• hyper- and dysplastic, smaller and with hypolobulated nuclei in bone marrow at age 18 months

increased megakaryocyte cell number ( J:278804 )

• hyperplastic in bone marrow at age 18 months

thrombocytopenia ( J:278804 )

• in blood at age 18 months

increased B cell number ( J:278804 )

• more B220+ cells at ages 8-12 weeks and 18 months

• normal percentage of B cells in spleen at age 8-12 weeks

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:278804 )

• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells in spleen at age 8-12 weeks

abnormal effector T cell number ( J:278804 )

• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen at age 8-12 weeks

decreased lymphocyte cell number ( J:278804 )

• in blood at age 18 months

decreased double-negative T cell number ( J:278804 )

• reduced in thymus at age 8-12 weeks

decreased CD4-positive, alpha-beta T cell number ( J:278804 )

• at age 8-12 weeks and in spleen at age 18 months

• normal percentage in spleen at age 8-12 weeks

decreased CD8-positive, alpha-beta T cell number ( J:278804 )

• at age 8-12 weeks and in spleen at age 18 months

• reduced percentage in spleen at age 8-12 weeks

decreased hematopoietic stem cell number ( J:278804 )

• reduced number of long-term hematopoietic stem cells (LT-HSCs) in bone marrow at age 18 months

increased hematopoietic stem cell number ( J:278804 )

• in bone marrow at age 8-12 weeks

abnormal splenic cell ratio ( J:278804 )

• reduced percentage of T cells at age 8-12 weeks

• reduced percentage of CD8+ T cells at ages 8-12 weeks and 18 months

• increased percentage of CD4+ T cells at age 18 months

• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells at ages 8-12 weeks and 18 months

• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen ages 8-12 weeks and 18 months

• normal percentage of CD4+ T cells at age 8-12 weeks

• normal percentage of B cells at age 8-12 weeks

immune system

immune system phenotype ( J:278804 )

• normal spleen and thymus weight and histology at age 8-12 weeks

• normal percentage of B cells in spleen at age 8-12 weeks

• normal total, naive regulatory and effector T cell function in cytokine stimulation assays at age 8-12 weeks

• normal number of B cells in bone marrow other than pro-B cells at age 8-12 weeks

• normal number of long-term hematopoietic stem cells (LT-HSCs) in bone marrow at age 8-12 weeks

abnormal thymus cell ratio ( J:278804 )

• reduced CD4- CD8- double-negative T cell numbers at age 8-12 weeks

enlarged spleen ( J:278804 )

• at age 18 months

• normal spleen weight and histology at age 8-12 weeks

increased pro-B cell number ( J:278804 )

• in bone marrow at age 8-12 weeks

increased B cell number ( J:278804 )

• more B220+ cells at ages 8-12 weeks and 18 months

• normal percentage of B cells in spleen at age 8-12 weeks

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:278804 )

• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells in spleen at age 8-12 weeks

abnormal effector T cell number ( J:278804 )

• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen at age 8-12 weeks

decreased lymphocyte cell number ( J:278804 )

• in blood at age 18 months

decreased double-negative T cell number ( J:278804 )

• reduced in thymus at age 8-12 weeks

decreased CD4-positive, alpha-beta T cell number ( J:278804 )

• at age 8-12 weeks and in spleen at age 18 months

• normal percentage in spleen at age 8-12 weeks

decreased CD8-positive, alpha-beta T cell number ( J:278804 )

• at age 8-12 weeks and in spleen at age 18 months

• reduced percentage in spleen at age 8-12 weeks

abnormal splenic cell ratio ( J:278804 )

• reduced percentage of T cells at age 8-12 weeks

• reduced percentage of CD8+ T cells at ages 8-12 weeks and 18 months

• increased percentage of CD4+ T cells at age 18 months

• increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells at ages 8-12 weeks and 18 months

• reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen ages 8-12 weeks and 18 months

• normal percentage of CD4+ T cells at age 8-12 weeks

• normal percentage of B cells at age 8-12 weeks

skeleton

skeleton phenotype ( J:278804 )

N	• normal bone marrow cellularity and architecture at ages 8-12 weeks and 18 months

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