Analysis Tools
hematopoietic system
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• 1.8 larger than in wild-type mice
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• 2-fold higher proportions in the spleen compared to in wild-type mice
• 1.2-fold in the bone marrow
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• increased reactive oxygen species, oxidative stress, and decreased life span in red blood cells
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• however, red blood cell counts are normal in very young mice
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growth/size/body
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• 1.8 larger than in wild-type mice
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cellular
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• in embryonic fibroblasts with lose of ability to become automatically transformed during long-passage in vitro culture
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• in embryonic fibroblasts
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• in red blood cells
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immune system
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• 1.8 larger than in wild-type mice
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