Phenotypes associated with this allele

• Allele Symbol: Adcy3^tm2.1Drs
• Allele Name: targeted mutation 2.1, Daniel R Storm
• Allele ID: MGI:7260104
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Adcy3^tm2.1Drs/Adcy3^tm2.1Drs Ndor1^Tg(UBC-cre/ERT2)1Ejb/Ndor1^+	involves: 129 * 129X1/SvJ * C57BL/6	MGI:7260162
cn2	Adcy3^tm2.1Drs/Adcy3^tm2.1Drs Emx1^tm1(cre)Krj/Emx1^+	involves: 129S2/SvPas * 129X1/SvJ	MGI:7260161

Genotype
MGI:7260162

cn1

• Allelic Composition: Adcy3^tm2.1Drs/Adcy3^tm2.1Drs; Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/Ndor1⁺
• Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal response to new environment ( J:281839 )

• tamoxifen-administered adults show a slightly longer latency to feed than controls in the novelty-suppressed feeding test

behavioral despair ( J:281839 )

• adult mice administered tamoxifen orally show longer periods of immobility in the tail suspension test and the force swim test

decreased grooming behavior ( J:281839 )

• tamoxifen-administered adults exhibit a poor coat state, suggesting decreased grooming

hypoactivity ( J:281839 )

• tamoxifen-administered adults are less active than controls in their home cage during the night

abnormal circadian sleep/wake cycle ( J:281839 )

• tamoxifen-administered adults show altered sleep; the sleep-wake cycle is not very rhythmic

abnormal non-rapid eye movement sleep pattern ( J:281839 )

• mice have more NREM sleep in nighttime and less NREM sleep in daytime than controls

abnormal nest building behavior ( J:281839 )

• tamoxifen-administered adults perform poorly in nest building

homeostasis/metabolism

increased circulating corticosterone level ( J:281839 )

• tamoxifen-administered adults exhibit a higher level of corticosterone

Genotype
MGI:7260161

cn2

• Allelic Composition: Adcy3^tm2.1Drs/Adcy3^tm2.1Drs; Emx1^tm1(cre)Krj/Emx1⁺
• Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

behavior/neurological

abnormal object recognition memory ( J:281839 )

• in the novel object recognition test, mice do not recognize familiar objects as well as controls

abnormal response to new environment ( J:281839 )

• when feeding in a novel environment, mice are slower to feed than controls, indicating novelty-suppressed feeding

• however, mice show normal feeding in the home cage

impaired spatial learning ( J:281839 )

• in the Morris water maze, mice spend more time learning to identify the location of the hidden platform and do not recognize the previous location of the hidden platform as well as controls in the probe trial

abnormal long-term spatial reference memory ( J:281839 )

• in the Morris water maze, mice do not recognize the previous location of the hidden platform as well as controls in the probe trial

abnormal depression-related behavior ( J:281839 )

• mice exhibit a prodepression phenotype

behavioral despair ( J:281839 )

• mice exhibit longer periods of immobility in the tail-suspension test and in the forced swim test

hypoactivity ( J:281839 )

• mice are less active in home cages during the night time

• mice are less active and move a shorter distance in the open field test

• however, mice do not show reduced sociability or increased anxiety, spending similar time interacting with the target mouse as wild-type mice in the three-chamber sociability test and spending a similar period of time in the open arm as controls