Adcy3^tm2.1Drs
Targeted Allele Detail

Summary

• Symbol: Adcy3^tm2.1Drs
• Name: adenylate cyclase 3; targeted mutation 2.1, Daniel R Storm
• MGI ID: MGI:7260104
• Synonyms: AC3^flox, AC3^fr
• Gene: Adcy3 Location: Chr12:4183397-4263525 bp, + strand Genetic Position: Chr12, 1.99 cM, cytoband A-B
• Alliance: Adcy3^tm2.1Drs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:281839
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 3 was flanked by loxP sites and an FRT-flanked neomycin selection cassette was inserted downstream of the floxed exon. Flp-mediated recombination deleted the selection cassette leaving exon 3 floxed. (J:281839)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adcy3 Mutation: 42 strains or lines available

References

• Original: J:281839 Chen X, et al., Ablation of Type III Adenylyl Cyclase in Mice Causes Reduced Neuronal Activity, Altered Sleep Pattern, and Depression-like Phenotypes. Biol Psychiatry. 2016 Dec 1;80(11):836-848
• All: 4 reference(s)