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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Otulinem1Gvl
endonuclease-mediated mutation 1, Geert van Loo
MGI:7256497
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Otulinem1Gvl/Otulinem1Gvl C57BL/6J-Otulinem1Gvl MGI:7256599
cn2
 		Otulinem1Gvl/Otulintm1c(EUCOMM)Hmgu
Tg(KRT14-cre)1Cgn/0 		involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA/2 MGI:7256600
cx3
 		Casp8tm1.1Raz/Casp8tm1.1Raz
Otulinem1Gvl/Otulinem1Gvl
Ripk3tm1Vmd/Ripk3tm1Vmd 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:7256604


Genotype
MGI:7256599
hm1
Allelic
Composition		 Otulinem1Gvl/Otulinem1Gvl
Genetic
Background		 C57BL/6J-Otulinem1Gvl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otulinem1Gvl mutation (0 available); any Otulin mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7256600
cn2
Allelic
Composition		 Otulinem1Gvl/Otulintm1c(EUCOMM)Hmgu
Tg(KRT14-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otulinem1Gvl mutation (0 available); any Otulin mutation (22 available)
Otulintm1c(EUCOMM)Hmgu mutation (0 available); any Otulin mutation (22 available)
Tg(KRT14-cre)1Cgn mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
dermatitis ( J:312394 )
• delineated inflamed skin lesions on back

integument
dermatitis ( J:312394 )
• delineated inflamed skin lesions on back
spontaneous skin ulceration ( J:312394 )
• delineated inflamed skin lesions on back

neoplasm
increased squamous cell carcinoma incidence ( J:312394 )
• verrucous carcinomas on back skin




Genotype
MGI:7256604
cx3
Allelic
Composition		 Casp8tm1.1Raz/Casp8tm1.1Raz
Otulinem1Gvl/Otulinem1Gvl
Ripk3tm1Vmd/Ripk3tm1Vmd
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8tm1.1Raz mutation (0 available); any Casp8 mutation (45 available)
Otulinem1Gvl mutation (0 available); any Otulin mutation (22 available)
Ripk3tm1Vmd mutation (1 available); any Ripk3 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryo phenotype ( J:312394 )
N
• mice born at normal Mendelian ratios

immune system
immune system phenotype ( J:312394 )
N
• no skin inflammation
enlarged lymph nodes ( J:312394 )
• lymphoproliferative syndrome by age 4 months

integument
integument phenotype ( J:312394 )
N
• no dermatitis and normal epidermal thickness




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory