All Phenotypes Rad51ap2<em1Qsh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rad51ap2^em1Qsh
endonuclease-mediated mutation 1, Qinghua Shi
MGI:6888019

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rad51ap2^em1Qsh/Rad51ap2^em1Qsh	involves: C57BL/6J * DBA/2J	MGI:6888119

Allelic Composition	Rad51ap2^em1Qsh/Rad51ap2^em1Qsh
Genetic Background	involves: C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad51ap2^em1Qsh mutation (0 available); any Rad51ap2 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:321708 )

N	• crossover formation and meiosis in oocytes is normal

oligozoospermia ( J:321708 )

increased male germ cell apoptosis ( J:321708 )

decreased testis weight ( J:321708 )

abnormal X-Y chromosome synapsis during male meiosis ( J:321708 )

• increased frequency of XY dissociation in meiotic metaphase I spermatocytes with reduced crossover and compromised double-strand break repair in the pseudoautosomal region

arrest of male meiosis ( J:321708 )

• unaligned chromosomes and reduced number of post-meiotic germ cells

endocrine/exocrine glands

decreased testis weight ( J:321708 )

cellular

oligozoospermia ( J:321708 )

increased male germ cell apoptosis ( J:321708 )

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