All Phenotypes Mios<tm1Pfw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mios^tm1Pfw
targeted mutation 1, Paul Worley
MGI:6887905

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mios^tm1Pfw/Mios^tm1Pfw Olig2^{tm2(TVA,cre)Rth}/Olig2⁺	involves: 129 * C57BL/6	MGI:6887924
cn2	Gt(ROSA)26Sor^{em2(Mios)Bcgen}/Gt(ROSA)26Sor⁺ Mios^tm1Pfw/Mios^tm1Pfw Olig2^{tm2(TVA,cre)Rth}/Olig2⁺	involves: 129 * C57BL/6	MGI:6887925
cn3	Mios^tm1Pfw/Mios^tm1Pfw Tg(Camk2a-cre)2Gsc/0	involves: C57BL/6 * FVB/N	MGI:6887926
cn4	Mios^tm1Pfw/Mios^tm1Pfw Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL	MGI:6887923

Allelic Composition	Mios^tm1Pfw/Mios^tm1Pfw Olig2^{tm2(TVA,cre)Rth}/Olig2⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mios^tm1Pfw mutation (0 available); any Mios mutation (39 available)
Olig2^{tm2(TVA,cre)Rth} mutation (1 available); any Olig2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:320720 )

N	• mice exhibit normal motor coordination and general activity levels/gross motor activity

nervous system

decreased oligodendrocyte number ( J:320720 )

• however, no increase in apoptosis was noted

abnormal oligodendrocyte physiology ( J:320720 )

• reduced proliferation of oligodendrocyte precursors due to delayed cell cycle exit

dysmyelination ( J:320720 )

• reduced number of myelinated optic nerves and in the corpus callosum

• reduced thickness of myelin wrap

• however, the distribution of axon diameters in the optic nerve is normal

Allelic Composition	Gt(ROSA)26Sor^{em2(Mios)Bcgen}/Gt(ROSA)26Sor⁺ Mios^tm1Pfw/Mios^tm1Pfw Olig2^{tm2(TVA,cre)Rth}/Olig2⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{em2(Mios)Bcgen} mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Mios^tm1Pfw mutation (0 available); any Mios mutation (39 available)
Olig2^{tm2(TVA,cre)Rth} mutation (1 available); any Olig2 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:320720 )

N	• mice exhibit normal oligodendrocyte myelination

Allelic Composition	Mios^tm1Pfw/Mios^tm1Pfw Tg(Camk2a-cre)2Gsc/0
Genetic Background	involves: C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mios^tm1Pfw mutation (0 available); any Mios mutation (39 available)
Tg(Camk2a-cre)2Gsc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:320720 )

N	• mice exhibit normal axonal growth and myelination

Allelic Composition	Mios^tm1Pfw/Mios^tm1Pfw Tg(Nes-cre)1Kln/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mios^tm1Pfw mutation (0 available); any Mios mutation (39 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased brain size ( J:320720 )

• slightly

abnormal forebrain morphology ( J:320720 )

• reduced gray and white matter

decreased oligodendrocyte number ( J:320720 )

dysmyelination ( J:320720 )

• in the corpus callosum and cortex

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