All Phenotypes Tln2<em1Clo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tln2^em1Clo
endonuclease-mediated mutation 1, Cecilia Lo
MGI:6879498

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tln2^em1Clo/Tln2⁺ Tpm1^em1Clo/Tpm1⁺	involves: C57BL/6 * DBA/2	MGI:6885596

Allelic Composition	Tln2^em1Clo/Tln2⁺ Tpm1^em1Clo/Tpm1⁺
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tln2^em1Clo mutation (0 available); any Tln2 mutation (149 available)
Tpm1^em1Clo mutation (0 available); any Tpm1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

atrial septal defect ( J:320916 )

• large ASD in surviving embryos at stage E16.5-17.5

• normal sarcomere organization

mortality/aging

embryonic lethality between implantation and placentation, incomplete penetrance ( J:320916 )

• lack of heartbeat initiation in 50% of E8.5 embryos (compared to 96% for Tpm1^em1Clo-only embryos)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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