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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tpm1em1Clo
endonuclease-mediated mutation 1, Cecilia Lo
MGI:6879497
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Tpm1em1Clo/Tpm1+ Not Specified MGI:6885597
cx2
 		Tln2em1Clo/Tln2+
Tpm1em1Clo/Tpm1+ 		involves: C57BL/6 * DBA/2 MGI:6885596


Genotype
MGI:6885597
ht1
Allelic
Composition		 Tpm1em1Clo/Tpm1+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tpm1em1Clo mutation (0 available); any Tpm1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal endocardial heart tube morphology ( J:320916 )
• abnormal looping in E9.5 embryos
• reduced cell proliferation in E9.5 embryos
abnormal heart looping ( J:320916 )
• in E9.5 embryos
pericardial effusion ( J:320916 )
• severe pericardial effusion in E9.5 embryos
absent heartbeat ( J:320916 )
• in E8.5 embryos

mortality/aging
embryonic lethality between implantation and placentation, complete penetrance ( J:320916 )
• lack of heartbeat initiation in E8.5 embryos, followed by death or resorption by E9.5

homeostasis/metabolism
pericardial effusion ( J:320916 )
• severe pericardial effusion in E9.5 embryos
hydrops fetalis ( J:320916 )
• in E9.5 embryos




Genotype
MGI:6885596
cx2
Allelic
Composition		 Tln2em1Clo/Tln2+
Tpm1em1Clo/Tpm1+
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tln2em1Clo mutation (0 available); any Tln2 mutation (149 available)
Tpm1em1Clo mutation (0 available); any Tpm1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
atrial septal defect ( J:320916 )
• large ASD in surviving embryos at stage E16.5-17.5
• normal sarcomere organization

mortality/aging
embryonic lethality between implantation and placentation, incomplete penetrance ( J:320916 )
• lack of heartbeat initiation in 50% of E8.5 embryos (compared to 96% for Tpm1em1Clo-only embryos)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory