Phenotypes associated with this allele

• Allele Symbol: Actmap^em1Nki
• Allele Name: endonuclease-mediated mutation 1, The Netherlands Cancer Institute
• Allele ID: MGI:6831070
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Actmap^em1Nki/Actmap^em1Nki	FVB/N-Actmap^em1Nki	MGI:7423599

Genotype
MGI:7423599

hm1

• Allelic Composition: Actmap^em1Nki/Actmap^em1Nki
• Genetic Background: FVB/N-Actmap^em1Nki

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased grip strength ( J:331923 )

• mice show decreased muscle strength by about 12% and about 11% in males and females, respectively, as measured by grip strength

muscle

abnormal skeletal muscle fiber morphology ( J:331923 )

• thin filaments are on average about 8.4% shorter in soleus muscle

centrally nucleated skeletal muscle fibers ( J:331923 )

• 50-week-old mice exhibit an age-dependent, 8-fold increase in centrally located nuclei within muscle fibers, indicating ongoing muscle repair after injury

impaired skeletal muscle contractility ( J:331923 )

• isolated intact soleus muscles generate about 11% lower absolute maximal force compared to wild-type muscles

muscle weakness ( J:331923 )

• mice show decreased muscle strength by about 12% and about 11% in males and females, respectively, as measured by grip strength

cellular

abnormal actin cytoskeleton morphology ( J:331923 )

• mice show absence of cytoplasmic actin processing across all tissues resulting in a cytoskeleton composed of immature actin molecules

mortality/aging

mortality/aging ( J:331923 )

N • mice are viable and born at expected ratios and show no obvious genotype-specific morbidity during the first year of life