Phenotypes associated with this allele

• Allele Symbol: Nup210^tm1.1Mdan
• Allele Name: targeted mutation 1.1, Maximiliano A D'Angelo
• Allele ID: MGI:6830911
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nup210^tm1.1Mdan/Nup210^tm1.1Mdan	B6.Cg-Nup210^tm1.1Mdan	MGI:6830958

Genotype
MGI:6830958

hm1

• Allelic Composition: Nup210^tm1.1Mdan/Nup210^tm1.1Mdan
• Genetic Background: B6.Cg-Nup210^tm1.1Mdan

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:282451 )

N • mice exhibit normal numbers of erythrocytes, myeloid cells, CD8+ T cells, natural killer T cells, and regulatory T cells in addition to normal T cell development and circulation

decreased leukocyte cell number ( J:282451 )

abnormal lymphocyte morphology ( J:282451 )

• lower proportion and numbers of CD3+ T lymphocytes

abnormal CD4-positive, alpha-beta T cell number ( J:282451 )

• increase in naive CD4+ T cells in the spleen and blood

decreased CD4-positive, alpha-beta T cell number ( J:282451 )

increased effector memory T-helper cell number ( J:282451 )

• in the spleen

abnormal CD4-positive, alpha-beta T cell physiology ( J:282451 )

• cell-intrinsic reduction in naive CD4+ T cell survival in the periphery

abnormal T cell activation ( J:282451 )

• impaired CD4+ T cell activation

immune system

decreased leukocyte cell number ( J:282451 )

abnormal lymphocyte morphology ( J:282451 )

• lower proportion and numbers of CD3+ T lymphocytes

abnormal CD4-positive, alpha-beta T cell number ( J:282451 )

• increase in naive CD4+ T cells in the spleen and blood

decreased CD4-positive, alpha-beta T cell number ( J:282451 )

increased effector memory T-helper cell number ( J:282451 )

• in the spleen

abnormal CD4-positive, alpha-beta T cell physiology ( J:282451 )

• cell-intrinsic reduction in naive CD4+ T cell survival in the periphery

abnormal T cell activation ( J:282451 )

• impaired CD4+ T cell activation