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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Surf4em1Bcgen
endonuclease-mediated mutation 1, Biocytogen LLC
MGI:6830906
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Surf4em1Bcgen/Surf4em1Bcgen C57BL/6J-Surf4em1Bcgen MGI:6830908
cn2
 		Surf4em1Bcgen/Surf4+ C57BL/6J-Surf4em1Bcgen MGI:6830909


Genotype
MGI:6830908
cn1
Allelic
Composition		 Surf4em1Bcgen/Surf4em1Bcgen
Genetic
Background		 C57BL/6J-Surf4em1Bcgen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Surf4em1Bcgen mutation (0 available); any Surf4 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating cholesterol level ( J:302969 )
• in mice treated with a cre-expressing advenovirus in the liver
• in refed mice treated with a cre-expressing advenovirus in the liver
decreased circulating triglyceride level ( J:302969 )
• in mice treated with a cre-expressing advenovirus in the liver
• in refed mice treated with a cre-expressing advenovirus in the liver
increased liver cholesterol level ( J:302969 )
• in mice treated with a cre-expressing advenovirus in the liver

cardiovascular system
decreased susceptibility to atherosclerosis ( J:302969 )
• in mice treated with advenoviruses expressing cre and PCSK9 in the liver

liver/biliary system
increased liver cholesterol level ( J:302969 )
• in mice treated with a cre-expressing advenovirus in the liver




Genotype
MGI:6830909
cn2
Allelic
Composition		 Surf4em1Bcgen/Surf4+
Genetic
Background		 C57BL/6J-Surf4em1Bcgen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Surf4em1Bcgen mutation (0 available); any Surf4 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating cholesterol level ( J:302969 )
• intermediate in refed mice treated with a cre-expressing advenovirus in the liver
decreased circulating triglyceride level ( J:302969 )
• intermediate in refed mice treated with a cre-expressing advenovirus in the liver




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory