Phenotypes associated with this allele

• Allele Symbol: Zfp212^em1Jhsn
• Allele Name: endonuclease-mediated mutation 1, Joo-Ho Shin
• Allele ID: MGI:6830528
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp212^em1Jhsn/Zfp212^em1Jhsn	C57BL/6-Zfp212^em1Jhsn	MGI:6830530

Genotype
MGI:6830530

hm1

• Allelic Composition: Zfp212^em1Jhsn/Zfp212^em1Jhsn
• Genetic Background: C57BL/6-Zfp212^em1Jhsn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:314906 )

• less than half of mice die approximately at 22 months of age

nervous system

Purkinje cell degeneration ( J:314906 )

• however, rescued by treatment with an adenovirus expressing the human gene

abnormal Purkinje cell dendrite morphology ( J:314906 )

• short dendrites

decreased Purkinje cell number ( J:314906 )

• at 8 weeks in the cerebellum

• at 3 months in motor-associated lobules I/II, III, IV/V, and VIII

behavior/neurological

decreased thigmotaxis ( J:314906 )

• in an open field

impaired coordination ( J:314906 )

• on a rotarod

abnormal gait ( J:314906 )

• decreased front and hind base widths