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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Paxbp1tm1.1Nju
targeted mutation 1.1, Model Animal Research Center of Nanjing University
MGI:6827438
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Pax7tm1(cre)Mrc/Pax7tm1(cre)Mrc
Paxbp1tm1.1Nju/Paxbp1tm1.1Nju 		involves: 129S1/Sv * 129X1/SvJ MGI:6827450
cn2
 		Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sortm1(EYFP)Cos
Pax7tm1(cre/ERT2)Gaka/Pax7tm1(cre/ERT2)Gaka
Paxbp1tm1.1Nju/Paxbp1tm1.1Nju 		involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCr MGI:6827448


Genotype
MGI:6827450
cn1
Allelic
Composition		 Pax7tm1(cre)Mrc/Pax7tm1(cre)Mrc
Paxbp1tm1.1Nju/Paxbp1tm1.1Nju
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax7tm1(cre)Mrc mutation (3 available); any Pax7 mutation (39 available)
Paxbp1tm1.1Nju mutation (0 available); any Paxbp1 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:6827448
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sortm1(EYFP)Cos
Pax7tm1(cre/ERT2)Gaka/Pax7tm1(cre/ERT2)Gaka
Paxbp1tm1.1Nju/Paxbp1tm1.1Nju
Genetic
Background		 involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(EYFP)Cos mutation (11 available); any Gt(ROSA)26Sor mutation (944 available)
Pax7tm1(cre/ERT2)Gaka mutation (1 available); any Pax7 mutation (39 available)
Paxbp1tm1.1Nju mutation (0 available); any Paxbp1 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitochondrial morphology ( J:304562 )
• fragmented mitochondria, largely restricted to perinuclear region, lacking interconnecting tubular network in activated muscle stem cells
abnormal respiratory electron transport chain ( J:304562 )
• defective cellular respiration and glycolysis
abnormal mitochondrial ATP synthesis coupled electron transport ( J:304562 )
• defective cellular respiration and glycolysis
decreased mitochondrial fission ( J:304562 )
• defective mitochondrial biogenesis in activated muscle stem cells
abnormal oxidative phosphorylation ( J:304562 )
• defective cellular respiration and glycolysis

muscle
impaired skeletal muscle regeneration ( J:304562 )
• virtual absence of regenerating myofibers 5 days after injection of cardiotoxin (CTX) into the tibialis anterior (TA) muscles and no muscle regeneration after 14 nor 30 days
• adipocyte infiltration 30 days after injection of cardiotoxin (CTX) into the tibialis anterior (TA) muscles




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory