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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Actl7aem1Fzh
endonuclease-mediated mutation 1, Feng Zhang
MGI:6827375
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Actl7aem1Fzh/Actl7aem1Fzh C57BL/6-Actl7aem1Fzh MGI:6827377


Genotype
MGI:6827377
hm1
Allelic
Composition		 Actl7aem1Fzh/Actl7aem1Fzh
Genetic
Background		 C57BL/6-Actl7aem1Fzh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actl7aem1Fzh mutation (0 available); any Actl7a mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:313844 )
N
• female mice exhibit normal fertility
abnormal acrosome morphology ( J:313844 )
• cap-like structure with increased subacrosomal layer and the post-acrosomal sheath in the perinuclear theca
male infertility ( J:313844 )
• despite normal semen characteristics, testis size, and testis weight
impaired fertilization ( J:313844 )
• sperm are unable to fertilize oocytes by in vitro fertilization and intracytoplasmic sperm injection
• however, artificial oocyte activation following intracytoplasmic sperm injection restores fertilization

cellular
abnormal acrosome morphology ( J:313844 )
• cap-like structure with increased subacrosomal layer and the post-acrosomal sheath in the perinuclear theca




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory