Actl7a^em1Fzh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Actl7a^em1Fzh
• Name: actin-like 7a; endonuclease-mediated mutation 1, Feng Zhang
• MGI ID: MGI:6827375
• Synonyms: Actl7a^KI
• Gene: Actl7a Location: Chr4:56743422-56744925 bp, + strand Genetic Position: Chr4, 31.66 cM
• Alliance: Actl7a^em1Fzh page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced a nucleotide substitution (G to A) that results in the amino acid substitution of alanine with threonine at position 250 (A250T). (J:313844)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Actl7a Mutation: 16 strains or lines available

References

• Original: J:313844 Xin A, et al., Disruption in ACTL7A causes acrosomal ultrastructural defects in human and mouse sperm as a novel male factor inducing early embryonic arrest. Sci Adv. 2020 Aug;6(35):eaaz4796
• All: 1 reference(s)