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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gm40600em1Cya
endonuclease-mediated mutation 1, Cyagen Biosciences
MGI:6794076
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gm40600em1Cya/Gm40600em1Cya C57BL/6-Gm40600em1Cya MGI:6798137


Genotype
MGI:6798137
hm1
Allelic
Composition		 Gm40600em1Cya/Gm40600em1Cya
Genetic
Background		 C57BL/6-Gm40600em1Cya
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:311878 )
N
• normal levels of prepro, pro- and pre-B cells in bone marrow (BM), immature (T1, T2 and T2) and mature (FO and MZ) B cells and total B cells in spleen
decreased B cell number ( J:311878 )
• reduced number of CD38-lo GL7-hi B220+ CD19+ GC B cells after stimulation with sheep red blood cells (SRCs)
decreased plasma cell number ( J:311878 )
• reduced number of TAC1+ CD138+ B220- CD19-int early and TAC1+ CD138+ B220- CD19- mature PCs after stimulation with sheep red blood cells (SRCs)
increased B cell number ( J:311878 )
• CD38-lo GL7-hi B220+ CD19+ GC B cells in naive mice and CD38-lo GL7-hi B220+ GC B cells after priming with NP-Ficoll
increased plasma cell number ( J:311878 )
• increased number of TAC1+ CD138+ B220- CD19-int early and TAC1+ CD138+ B220- CD19- mature PCs in naive mice or after priming with NP-Ficoll
abnormal plasmablast number ( J:311878 )
• increased number of TAC1+ CD138+ B220-int CD19-int PBs in naive mice or after priming with NP-Ficoll
• reduced number of TAC1+ CD138+ B220-int CD19-int PBs after stimulation with sheep red blood cells (SRCs)
decreased IgA level ( J:311878 )
• after stimulation with sheep red blood cells (SRCs)
increased IgA level ( J:311878 )
• in naive mice or after priming with NP-Ficoll
decreased IgE level ( J:311878 )
• after stimulation with sheep red blood cells (SRCs)
increased IgE level ( J:311878 )
• in naive mice or after priming with NP-Ficoll
decreased IgG level ( J:311878 )
• after stimulation with sheep red blood cells (SRCs)
decreased IgG1 level ( J:311878 )
• after stimulation with sheep red blood cells (SRCs)
decreased IgG2b level ( J:311878 )
• after stimulation with sheep red blood cells (SRCs)
decreased IgG2c level ( J:311878 )
• after stimulation with sheep red blood cells (SRCs)
decreased IgG3 level ( J:311878 )
• after stimulation with sheep red blood cells (SRCs)
increased IgG level ( J:311878 )
• in naive mice or after priming with NP-Ficoll
increased IgG1 level ( J:311878 )
• in naive mice or after priming with NP-Ficoll
increased IgG2b level ( J:311878 )
• in naive mice or after priming with NP-Ficoll
increased IgG2c level ( J:311878 )
• in naive mice or after priming with NP-Ficoll
increased IgG3 level ( J:311878 )
• in naive mice or after priming with NP-Ficoll
decreased IgM level ( J:311878 )
• after stimulation with sheep red blood cells (SRCs)
increased IgM level ( J:311878 )
• in naive mice or after priming with NP-Ficoll

hematopoietic system
decreased B cell number ( J:311878 )
• reduced number of CD38-lo GL7-hi B220+ CD19+ GC B cells after stimulation with sheep red blood cells (SRCs)
decreased plasma cell number ( J:311878 )
• reduced number of TAC1+ CD138+ B220- CD19-int early and TAC1+ CD138+ B220- CD19- mature PCs after stimulation with sheep red blood cells (SRCs)
increased B cell number ( J:311878 )
• CD38-lo GL7-hi B220+ CD19+ GC B cells in naive mice and CD38-lo GL7-hi B220+ GC B cells after priming with NP-Ficoll
increased plasma cell number ( J:311878 )
• increased number of TAC1+ CD138+ B220- CD19-int early and TAC1+ CD138+ B220- CD19- mature PCs in naive mice or after priming with NP-Ficoll
abnormal plasmablast number ( J:311878 )
• increased number of TAC1+ CD138+ B220-int CD19-int PBs in naive mice or after priming with NP-Ficoll
• reduced number of TAC1+ CD138+ B220-int CD19-int PBs after stimulation with sheep red blood cells (SRCs)
decreased IgA level ( J:311878 )
• after stimulation with sheep red blood cells (SRCs)
increased IgA level ( J:311878 )
• in naive mice or after priming with NP-Ficoll
decreased IgE level ( J:311878 )
• after stimulation with sheep red blood cells (SRCs)
increased IgE level ( J:311878 )
• in naive mice or after priming with NP-Ficoll
decreased IgG level ( J:311878 )
• after stimulation with sheep red blood cells (SRCs)
decreased IgG1 level ( J:311878 )
• after stimulation with sheep red blood cells (SRCs)
decreased IgG2b level ( J:311878 )
• after stimulation with sheep red blood cells (SRCs)
decreased IgG2c level ( J:311878 )
• after stimulation with sheep red blood cells (SRCs)
decreased IgG3 level ( J:311878 )
• after stimulation with sheep red blood cells (SRCs)
increased IgG level ( J:311878 )
• in naive mice or after priming with NP-Ficoll
increased IgG1 level ( J:311878 )
• in naive mice or after priming with NP-Ficoll
increased IgG2b level ( J:311878 )
• in naive mice or after priming with NP-Ficoll
increased IgG2c level ( J:311878 )
• in naive mice or after priming with NP-Ficoll
increased IgG3 level ( J:311878 )
• in naive mice or after priming with NP-Ficoll
decreased IgM level ( J:311878 )
• after stimulation with sheep red blood cells (SRCs)
increased IgM level ( J:311878 )
• in naive mice or after priming with NP-Ficoll




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory