Phenotypes associated with this allele

• Allele Symbol: Rem1^tm1Jsat
• Allele Name: targeted mutation 1, Jonathan Satin
• Allele ID: MGI:6760672
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rem1^tm1Jsat/Rem1^tm1Jsat	involves: 129S6/SvEvTac * Black Swiss	MGI:7433116

Genotype
MGI:7433116

hm1

• Allelic Composition: Rem1^tm1Jsat/Rem1^tm1Jsat
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:309872 )

N • mice grow to adulthood without displaying an overt cardiac phenotype at baseline

abnormal myocardial fiber calcium currents ( J:309872 )

• ventricular cardiomyocytes show increased L-type calcium channel current (I_Ca,L) density relative to wild-type cardiomyocytes

• midpoint of steady-state activation (V ) is significantly shifted +4 mV relative to wild type myocytes; beta-adrenergic stimulation normalizes the shift of activation V such that isoproterenol-modulated channel voltage-dependence is no longer significantly different from wild-type controls

• despite increased I_Ca,L density, cardiomyocyte Ca²⁺ twitch transient amplitude is significantly less than that in wild-type myocytes

• however, current kinetics, steady-state inactivation and facilitation remain normal and cell shortening is not significantly altered