Rem1^tm1Jsat
Targeted Allele Detail

Summary

• Symbol: Rem1^tm1Jsat
• Name: rad and gem related GTP binding protein 1; targeted mutation 1, Jonathan Satin
• MGI ID: MGI:6760672
• Synonyms: Rem^-
• Gene: Rem1 Location: Chr2:152468928-152477111 bp, + strand Genetic Position: Chr2, 75.41 cM, cytoband H2
• Alliance: Rem1^tm1Jsat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:309872
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a lacZ expressing cassette and an FRT-flanked neomycin selection gene. Immunoblot analysis confirmed the complete absence of protein expression in cardiac muscle of homozygous mutant mice. (J:309872)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rem1 Mutation: 21 strains or lines available

References

• Original: J:309872 Magyar J, et al., Rem-GTPase regulates cardiac myocyte L-type calcium current. Channels (Austin). 2012 May-Jun;6(3):166-73
• All: 1 reference(s)