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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnfem5Boui
endonuclease-mediated mutation 5, Philippe Bouillet
MGI:6729296
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tnfem5Boui/Tnfem5Boui C57BL/6-Tnfem5Boui MGI:6730106
cx2
 		Tnfem5Boui/Tnf+
Tnfrsf1atm1Mak/Tnfrsf1a+ 		involves: 129S2/SvPas * C57BL/6 MGI:6730103


Genotype
MGI:6730106
hm1
Allelic
Composition		 Tnfem5Boui/Tnfem5Boui
Genetic
Background		 C57BL/6-Tnfem5Boui
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfem5Boui mutation (0 available); any Tnf mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:6730103
cx2
Allelic
Composition		 Tnfem5Boui/Tnf+
Tnfrsf1atm1Mak/Tnfrsf1a+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfem5Boui mutation (0 available); any Tnf mutation (46 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system

digestive/alimentary system
colitis ( J:306876 )
• inflammatory bowel disease (IBD) in gut in surviving mice at age P20

immune system
colitis ( J:306876 )
• inflammatory bowel disease (IBD) in gut in surviving mice at age P20
arthritis ( J:306876 )
• deformed ankles and wrists in surviving mice from age P7
• large pannus tissue invasion in synovial joints in surviving mice at age P20

mortality/aging
premature death ( J:306876 )
• surviving mice die by age 33 days
preweaning lethality, incomplete penetrance ( J:306876 )
• 80% of embryos die within hours of birth

respiratory system
abnormal lung morphology ( J:306876 )
• failure to initiate respiration: underinflated lungs in pups that died within hours of birth

skeleton
arthritis ( J:306876 )
• deformed ankles and wrists in surviving mice from age P7
• large pannus tissue invasion in synovial joints in surviving mice at age P20




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory