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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tulp2em1Huizh
endonuclease-mediated mutation 1, Hui Zhu
MGI:6724546
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tulp2em1Huizh/Tulp2em1Huizh C57BL/6-Tulp2em1Huizh MGI:6724569


Genotype
MGI:6724569
hm1
Allelic
Composition		 Tulp2em1Huizh/Tulp2em1Huizh
Genetic
Background		 C57BL/6-Tulp2em1Huizh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tulp2em1Huizh mutation (0 available); any Tulp2 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:307539 )
N
• fertile and normal litter size
abnormal sperm axoneme morphology ( J:307539 )
• incomplete or disorganized 2+9 microtubule arrangement
abnormal sperm midpiece morphology ( J:307539 )
• incomplete peripheral dense fibers
kinked sperm flagellum ( J:307539 )
• in cauda, caput and corpus epididymis
oligozoospermia ( J:307539 )
• low sperm count in cauda epididymis and lumen of epididymis duct
abnormal spermatid morphology ( J:307539 )
• retained elongated spermatids in middle and base of stage VII-X seminiferous tubules
increased testis apoptosis ( J:307539 )
• significant increase in average number of apoptotic cells per tubule
• significant increase in elongated spermatid apoptosis
decreased sperm progressive motility ( J:307539 )
• low progressive motility of sperm from cauda epididymis
asthenozoospermia ( J:307539 )
• low motility of sperm from cauda epididymis

endocrine/exocrine glands
increased testis apoptosis ( J:307539 )
• significant increase in average number of apoptotic cells per tubule
• significant increase in elongated spermatid apoptosis

cellular
abnormal sperm axoneme morphology ( J:307539 )
• incomplete or disorganized 2+9 microtubule arrangement
abnormal sperm midpiece morphology ( J:307539 )
• incomplete peripheral dense fibers
kinked sperm flagellum ( J:307539 )
• in cauda, caput and corpus epididymis
oligozoospermia ( J:307539 )
• low sperm count in cauda epididymis and lumen of epididymis duct
abnormal spermatid morphology ( J:307539 )
• retained elongated spermatids in middle and base of stage VII-X seminiferous tubules
abnormal mitochondrial crista morphology ( J:307539 )
• absent inner mitochondrial membrane cristae in sperm flagella
increased testis apoptosis ( J:307539 )
• significant increase in average number of apoptotic cells per tubule
• significant increase in elongated spermatid apoptosis
decreased sperm progressive motility ( J:307539 )
• low progressive motility of sperm from cauda epididymis
asthenozoospermia ( J:307539 )
• low motility of sperm from cauda epididymis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory