Tulp2^em1Huizh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tulp2^em1Huizh
• Name: TUB like protein 2; endonuclease-mediated mutation 1, Hui Zhu
• MGI ID: MGI:6724546
• Synonyms: Tulp2^-
• Gene: Tulp2 Location: Chr7:45131450-45173070 bp, + strand Genetic Position: Chr7, 29.33 cM
• Alliance: Tulp2^em1Huizh page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 2 was targeted with an sgRNA using CRISPR/Cas9 technology, resulting in a 49 bp deletion. Western blot and immunohistochemistry experiments confirmed the lack of peptide expression from this allele in testes. (J:307539)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tulp2 Mutation: 53 strains or lines available

References

• Original: J:307539 Zheng M, et al., TULP2, a New RNA-Binding Protein, Is Required for Mouse Spermatid Differentiation and Male Fertility. Front Cell Dev Biol. 2021;9:623738
• All: 1 reference(s)