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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prrc2atm1Fcw
targeted mutation 1, Fengchao Wang
MGI:6724325
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Prrc2atm1Fcw/Prrc2atm1Fcw
Olig2tm2(TVA,cre)Rth/Olig2+ 		involves: 129 * C57BL/6 MGI:6724442
cn2
 		Prrc2atm1Fcw/Prrc2atm1Fcw
Tg(Gfap-cre)77.6Mvs/0 		involves: BALB/c * C57BL/6NHsd MGI:6724443
cn3
 		Prrc2atm1Fcw/Prrc2atm1Fcw
Tg(Nes-cre)1Kln/0 		involves: C57BL/6 * SJL MGI:6724441


Genotype
MGI:6724442
cn1
Allelic
Composition		 Prrc2atm1Fcw/Prrc2atm1Fcw
Olig2tm2(TVA,cre)Rth/Olig2+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Olig2tm2(TVA,cre)Rth mutation (1 available); any Olig2 mutation (46 available)
Prrc2atm1Fcw mutation (0 available); any Prrc2a mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system
nervous system phenotype ( J:301796 )
N
• mice exhibit normal ventral neuron numbers in the spinal cord
abnormal brain morphology ( J:301796 )
• however, neuron number is normal
abnormal corpus callosum morphology ( J:301796 )
• increased signal density on MRIs
• hypomyelination in the corpus callosum at 4 weeks of age and in adults

growth/size/body
decreased body weight ( J:301796 )

behavior/neurological

cellular




Genotype
MGI:6724443
cn2
Allelic
Composition		 Prrc2atm1Fcw/Prrc2atm1Fcw
Tg(Gfap-cre)77.6Mvs/0
Genetic
Background		 involves: BALB/c * C57BL/6NHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prrc2atm1Fcw mutation (0 available); any Prrc2a mutation (62 available)
Tg(Gfap-cre)77.6Mvs mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:301796 )
N
• mice exhibit normal myelination and oligodendrocyte and astrocyte populations




Genotype
MGI:6724441
cn3
Allelic
Composition		 Prrc2atm1Fcw/Prrc2atm1Fcw
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prrc2atm1Fcw mutation (0 available); any Prrc2a mutation (62 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system
abnormal brain morphology ( J:301796 )
• however, neuron number is normal
abnormal brain development ( J:301796 )
• impaired oligodendrocyte progenitor cell generation and proliferation with increased oligodendrocyte differentiation
abnormal corpus callosum morphology ( J:301796 )
• increased signal density on MRIs
• hypomyelination in the corpus callosum at 4 weeks of age and in adults
abnormal astrocyte physiology ( J:301796 )
• reduced proliferation
dysmyelination ( J:301796 )
• in the corpus callosum at 4 weeks of age and in adults
• reduced myelinated axons and myelin thickness in different brain regions
decreased nerve conduction velocity ( J:301796 )
• impaired callosal conduction velocity

growth/size/body
decreased body weight ( J:301796 )

behavior/neurological
impaired spatial learning ( J:301796 )
• learning and memory defects
impaired coordination ( J:301796 )
• on a rotarod

cellular




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory