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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Agap3tm1Ygi
targeted mutation 1, Shigeru Yanagi
MGI:6719542
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Agap3tm1Ygi/Agap3tm1Ygi
Tg(Emx1-cre)#Ito/0 		involves: C57BL/6 MGI:6719550
cn2
 		Agap3tm1Ygi/Agap3tm1Ygi
Tg(Nes-cre)1Kln/0 		involves: C57BL/6 * SJL MGI:6719551


Genotype
MGI:6719550
cn1
Allelic
Composition		 Agap3tm1Ygi/Agap3tm1Ygi
Tg(Emx1-cre)#Ito/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agap3tm1Ygi mutation (0 available); any Agap3 mutation (38 available)
Tg(Emx1-cre)#Ito mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal dentate gyrus morphology ( J:306994 )
• immature dentate gyrus with decreased mature neuron numbers
decreased neuron number ( J:306994 )
• decreased mature neurons in the dentate gyrus

behavior/neurological
hyperactivity ( J:306994 )
• at P21 and 8 weeks without increased anxiety




Genotype
MGI:6719551
cn2
Allelic
Composition		 Agap3tm1Ygi/Agap3tm1Ygi
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agap3tm1Ygi mutation (0 available); any Agap3 mutation (38 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:306994 )
• survival is similar to in Agap3tm1.1Ygi homozygotes

growth/size/body
decreased body size ( J:306994 )
decreased body weight ( J:306994 )

behavior/neurological
hyperactivity ( J:306994 )
• hyperactivity and increased distance traveled in an open-field test
increased locomotor activity ( J:306994 )
• in an open field test




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory