Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shld1em1Nus mutation
(0 available);
any
Shld1 mutation
(78 available)
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immune system
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• mice show defects in IgG1 class switch recombination
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hematopoietic system
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• mice show defects in IgG1 class switch recombination
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mortality/aging
N |
• mice are viable and do not show any overt phenotypes
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2.1Cxd mutation
(1 available);
any
Brca1 mutation
(113 available)
Shld1em1Nus mutation
(0 available);
any
Shld1 mutation
(78 available)
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immune system
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• mice show defects in IgG1 class switch recombination
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hematopoietic system
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• mice show defects in IgG1 class switch recombination
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cellular
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• PARPi-induced genome instability is lower in primary B cells compared to that seen in homozygous Brca1 mutant cells but still increased compared to in wild-type cells
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mortality/aging
N |
• the expected Mendelian ratio of mice are obtained, indicating rescue of the embryonic lethality of homozygous Brca1 mutants
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