About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ikbipem1Bcgen
endonuclease-mediated mutation 1, Biocytogen LLC
MGI:6712194
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ikbipem1Bcgen/Ikbipem1Bcgen
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd MGI:6712195


Genotype
MGI:6712195
cn1
Allelic
Composition		 Ikbipem1Bcgen/Ikbipem1Bcgen
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbipem1Bcgen mutation (0 available); any Ikbip mutation (19 available)
Lyz2tm1(cre)Ifo mutation (16 available); any Lyz2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to bacterial infection induced morbidity/mortality ( J:282971 )
• increase in mortality after injection with high dose LPS (30 mg/kg)

immune system
increased susceptibility to induced colitis ( J:282971 )
• increased weight loss, higher colitis scores, and shorter colonic lengths following DSS induced colitis
decreased macrophage cytokine production ( J:282971 )
• primary peritoneal macrophages show higher TNF-alpha and IL6 expression and secretion following stimulation with LPS, PGN, or poly(I:C)
increased circulating interleukin-6 level ( J:282971 )
• 4h after LPS stimulation
lung inflammation ( J:282971 )
• increase in infiltration of immune cells and more severe injuries after LPS treatment
increased susceptibility to bacterial infection induced morbidity/mortality ( J:282971 )
• increase in mortality after injection with high dose LPS (30 mg/kg)

digestive/alimentary system
increased susceptibility to induced colitis ( J:282971 )
• increased weight loss, higher colitis scores, and shorter colonic lengths following DSS induced colitis

homeostasis/metabolism
increased circulating interleukin-6 level ( J:282971 )
• 4h after LPS stimulation

hematopoietic system
decreased macrophage cytokine production ( J:282971 )
• primary peritoneal macrophages show higher TNF-alpha and IL6 expression and secretion following stimulation with LPS, PGN, or poly(I:C)

respiratory system
lung inflammation ( J:282971 )
• increase in infiltration of immune cells and more severe injuries after LPS treatment




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory