About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zar1em1Hyfn
endonuclease-mediated mutation 1, Heng-Yu Fan
MGI:6696065
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zar1em1Hyfn/Zar1em1Hyfn involves: C57BL/6 * ICR MGI:6696072
cx2
 		Zar1em1Hyfn/Zar1em1Hyfn
Zar1lem1Hyfn/Zar1lem1Hyfn 		involves: C57BL/6 * ICR MGI:6696073


Genotype
MGI:6696072
hm1
Allelic
Composition		 Zar1em1Hyfn/Zar1em1Hyfn
Genetic
Background		 involves: C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zar1em1Hyfn mutation (0 available); any Zar1 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal female meiosis ( J:282460 )
• slightly slower germinal vesicle breakdown and slower first polar body release than in wild-type mice
impaired polar body extrusion ( J:282460 )
• slower first polar body release than in wild-type mice

cellular
abnormal female meiosis ( J:282460 )
• slightly slower germinal vesicle breakdown and slower first polar body release than in wild-type mice
impaired polar body extrusion ( J:282460 )
• slower first polar body release than in wild-type mice
maternal effect ( J:282460 )
• half of all embryos from females arrest at 1- to 2-cell stage




Genotype
MGI:6696073
cx2
Allelic
Composition		 Zar1em1Hyfn/Zar1em1Hyfn
Zar1lem1Hyfn/Zar1lem1Hyfn
Genetic
Background		 involves: C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zar1em1Hyfn mutation (0 available); any Zar1 mutation (17 available)
Zar1lem1Hyfn mutation (0 available); any Zar1l mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal female meiosis ( J:282460 )
• slower germinal vesicle breakdown and first polar body release than in wild-type mice
abnormal female meiosis I arrest ( J:282460 )
• some oocytes fail to release the polar body and arrest at metaphase I
• even occytes that release the first polar body arrest in cytokinesis
impaired polar body extrusion ( J:282460 )
• slower first polar body release than in wild-type mice

cellular
aneuploidy ( J:282460 )
• in telophase I-arrested oocytes
abnormal female meiosis ( J:282460 )
• slower germinal vesicle breakdown and first polar body release than in wild-type mice
abnormal female meiosis I arrest ( J:282460 )
• some oocytes fail to release the polar body and arrest at metaphase I
• even occytes that release the first polar body arrest in cytokinesis
impaired polar body extrusion ( J:282460 )
• slower first polar body release than in wild-type mice
maternal effect ( J:282460 )
• nearly all embryos from females arrest at 1-cell stage with none developed beyond the 2-cell stage
• impaired maternal 3UTR activation, mRNA translation, and accumulation during oocyte development




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory