All Phenotypes Myh3<tm1.2Sajm> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myh3^tm1.2Sajm/Myh3^tm1.2Sajm	involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6J	MGI:6695906
cn2	Myh3^tm1.2Sajm/Myh3^tm1.1Sajm Pax7^tm1(cre)Mrc/Pax7⁺	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J	MGI:6695908
cn3	Myh3^tm1.2Sajm/Myh3^tm1.1Sajm Pax3^tm1(cre)Joe/Pax3⁺	involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6J	MGI:6695907

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased myoblast apoptosis ( J:287755 )

• at age P0

growth/size/body

decreased body weight ( J:287755 )

• low birth weight

mortality/aging

prenatal lethality, incomplete penetrance ( J:287755 )

• mice are born at about half the expected Mendelian ratio

muscle

increased myoblast apoptosis ( J:287755 )

• at age P0

abnormal muscle precursor cell morphology ( J:287755 )

• reduction in Pax7+ myogenic precursor cells and in levels of committed myoblast marker MyoD peptide in E16.5 embryos

• normal number of Pax7+ myogenic precursor cells at age P0

decreased skeletal muscle fiber diameter ( J:287755 )

• in soleus at age P0, tibialis anterior (TA) and gastrocnemius at ages P15 and P30 and EDL at P15

• in extensor digitorum longus (EDL) at ages P0 and P30

increased skeletal muscle fiber number ( J:287755 )

• in extensor digitorum longus (EDL) and soleus at age P0

decreased skeletal muscle weight ( J:287755 )

• of tibialis anterior (TA), gastrocnemius and quadriceps at ages P15 and P30

abnormal skeletal muscle fiber type ratio ( J:287755 )

• increased number of MYH7+ (MyHC-slow) fibers in hind limb at age P0 and tibialis anterior (TA) and gastrocnemius at age P15

• in extensor digitorum longus (EDL) at age P15 and tibialis anterior (TA) and gastrocnemius at age P30

Allelic Composition	Myh3^tm1.2Sajm/Myh3^tm1.1Sajm Pax7^tm1(cre)Mrc/Pax7⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh3^tm1.1Sajm mutation (0 available); any Myh3 mutation (73 available)
Myh3^tm1.2Sajm mutation (0 available); any Myh3 mutation (73 available)
Pax7^tm1(cre)Mrc mutation (3 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle precursor cell morphology ( J:287755 )

• reduction in myogenic precursor marker Pax7 peptide level and 50% reduction in Pax7+ myogenic precursor cells in E16.5 embryos

• significantly reduced levels of committed myoblast markers MyoD and myogenin peptide levels and 60% reduction in MyoD+ myoblasts in E16.5 embryos

• 7x increased MyHC-slow peptide levels in E16.5 embryos

cellular

cellular phenotype ( J:287755 )

N	• normal apoptosis in E16.5 embryos

Allelic Composition	Myh3^tm1.2Sajm/Myh3^tm1.1Sajm Pax3^tm1(cre)Joe/Pax3⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh3^tm1.1Sajm mutation (0 available); any Myh3 mutation (73 available)
Myh3^tm1.2Sajm mutation (0 available); any Myh3 mutation (73 available)
Pax3^tm1(cre)Joe mutation (1 available); any Pax3 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle precursor cell morphology ( J:287755 )

• 50% reduction in myogenic precursor marker Pax7 peptide level in E13.5 embryos

• significantly increased levels of committed myoblast markers MyoD and myogenin peptide levels in E13.5 embryos

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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