Phenotypes associated with this allele

• Allele Symbol: Cdc14a^em1Jgao
• Allele Name: endonuclease-mediated mutation 1, Jiangang Gao
• Allele ID: MGI:6693771
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdc14a^em1Jgao/Cdc14a^em1Jgao	CBA/CaJ-Cdc14a^em1Jgao	MGI:6694136

Genotype
MGI:6694136

hm1

• Allelic Composition: Cdc14a^em1Jgao/Cdc14a^em1Jgao
• Genetic Background: CBA/CaJ-Cdc14a^em1Jgao

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:301219 )

♀N

teratozoospermia ( J:301219 )

♂ • in seminiferous tubules, caput epididymis, and cauda epididymis

coiled sperm flagellum ( J:301219 )

♂

abnormal sperm head morphology ( J:301219 )

♂

abnormal sperm nucleus morphology ( J:301219 )

♂ • increased sperm DNA compression

♂ • however, no DNA strand breaks

absent sperm head ( J:301219 )

♂ • some decapitated sperm

decreased male germ cell number ( J:301219 )

♂ • deteriorated at 4 months of age

decreased sperm progressive motility ( J:301219 )

♂

asthenozoospermia ( J:301219 )

♂

arrest of male meiosis ( J:301219 )

♂ • increased pachytene spermatocytes

reduced male fertility ( J:301219 )

♂

hearing/vestibular/ear

decreased cochlear hair cell number ( J:301219 )

• at 1 month of age, profound at 6 months of age

abnormal cochlear hair cell stereociliary bundle morphology ( J:301219 )

• at 1 and 6 months of age

increased or absent threshold for auditory brainstem response ( J:301219 )

• increasing with age

impaired hearing ( J:301219 )

• mice can only hear 70 dB

nervous system

decreased cochlear hair cell number ( J:301219 )

• at 1 month of age, profound at 6 months of age

abnormal cochlear hair cell stereociliary bundle morphology ( J:301219 )

• at 1 and 6 months of age

cellular

teratozoospermia ( J:301219 )

♂ • in seminiferous tubules, caput epididymis, and cauda epididymis

coiled sperm flagellum ( J:301219 )

♂

abnormal sperm head morphology ( J:301219 )

♂

abnormal sperm nucleus morphology ( J:301219 )

♂ • increased sperm DNA compression

♂ • however, no DNA strand breaks

absent sperm head ( J:301219 )

♂ • some decapitated sperm

decreased male germ cell number ( J:301219 )

♂ • deteriorated at 4 months of age

decreased sperm progressive motility ( J:301219 )

♂

asthenozoospermia ( J:301219 )

♂

paternal effect ( J:301219 )

♂ • poor embryonic development with sperm from null males with few developing blastocysts