Phenotypes associated with this allele

• Allele Symbol: Cnnm2^tm1.1Hmik
• Allele Name: targeted mutation 1.1, Hiroaki Miki
• Allele ID: MGI:6690510
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cnnm2^tm1.1Hmik/Cnnm2^tm1.1Hmik	involves: C57BL * C57BL/6J * DBA	MGI:6690621
ht2	Cnnm2^tm1.1Hmik/Cnnm2^+	involves: C57BL * C57BL/6J * DBA	MGI:6690623

Genotype
MGI:6690621

hm1

• Allelic Composition: Cnnm2^tm1.1Hmik/Cnnm2^tm1.1Hmik
• Genetic Background: involves: C57BL * C57BL/6J * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:303151 )

• no pups born; deviation from Mendelian ratio starting at stage E14.5

Genotype
MGI:6690623

ht2

• Allelic Composition: Cnnm2^tm1.1Hmik/Cnnm2⁺
• Genetic Background: involves: C57BL * C57BL/6J * DBA

cardiovascular system

decreased systemic arterial diastolic blood pressure ( J:303151 )

decreased systemic arterial systolic blood pressure ( J:303151 )

• in untreated animals and in mice subjected to unilateral nephrectomy and deoxycorticosterone acetate (DOCA)-salt treatment

homeostasis/metabolism

abnormal homeostasis ( J:303151 )

• reduced serum magnesium level

• normal urine and fecal magnesium level

decreased circulating magnesium level ( J:303151 )

mortality/aging

mortality/aging ( J:303151 )

N • viable